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Alfentanil Hydrochloride Injection
Alfentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation.
Alfentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Analgesia and sedation during anesthesia, Acute pain management in perioperative settings, Sedation in intensive care units.
At a glance
| Generic name | Alfentanil Hydrochloride Injection |
|---|---|
| Sponsor | The First Affiliated Hospital of Xinxiang Medical College |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Alfentanil acts as a selective agonist at mu opioid receptors, which are distributed throughout the brain and spinal cord. This binding modulates pain perception and produces sedative effects. Due to its rapid onset and short duration of action, alfentanil is particularly useful for intravenous administration in acute care settings such as anesthesia and intensive care.
Approved indications
- Analgesia and sedation during anesthesia
- Acute pain management in perioperative settings
- Sedation in intensive care units
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Chest wall rigidity
- Dizziness
Key clinical trials
- A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (PHASE4)
- Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement (PHASE4)
- Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?
- The Median Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg (PHASE4)
- Dexmedetomidine for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (PHASE4)
- Effect of a Bolus of 10 µg/kg of Alfentanil on the Pupillary Pain Index (NA)
- Early Detection of Epidural Onset by Temperature Change (NA)
- The Effect of an Opioid on the Lower Esophageal Sphincter During Anesthesia Induction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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