{"id":"alfentanil-hydrochloride-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Chest wall rigidity"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200531","moleculeType":"Small molecule","molecularWeight":"452.99"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alfentanil acts as a selective agonist at mu opioid receptors, which are distributed throughout the brain and spinal cord. This binding modulates pain perception and produces sedative effects. Due to its rapid onset and short duration of action, alfentanil is particularly useful for intravenous administration in acute care settings such as anesthesia and intensive care.","oneSentence":"Alfentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:19.887Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Analgesia and sedation during anesthesia"},{"name":"Acute pain management in perioperative settings"},{"name":"Sedation in intensive care units"}]},"trialDetails":[{"nctId":"NCT07347496","phase":"PHASE4","title":"A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Xinxiang Medical College","startDate":"2026-03-01","conditions":"Thoracic Surgery, Anesthesia, Non-intubated Anesthesia","enrollment":50},{"nctId":"NCT05881291","phase":"PHASE4","title":"Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2023-06-29","conditions":"Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia","enrollment":124},{"nctId":"NCT06212622","phase":"","title":"Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?","status":"COMPLETED","sponsor":"NHS Lothian","startDate":"2024-03-04","conditions":"Hip Injuries, Hip Fractures, Pain","enrollment":64},{"nctId":"NCT04969068","phase":"PHASE4","title":"The Median Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg","status":"UNKNOWN","sponsor":"Tianjin Nankai Hospital","startDate":"2021-07-23","conditions":"Anesthesia","enrollment":50},{"nctId":"NCT03521505","phase":"PHASE4","title":"Dexmedetomidine for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2018-05-11","conditions":"Bronchoscopy","enrollment":50},{"nctId":"NCT02646592","phase":"NA","title":"Effect of a Bolus of 10 µg/kg of Alfentanil on the Pupillary Pain Index","status":"COMPLETED","sponsor":"Pr Isabelle CONSTANT","startDate":"2016-04","conditions":"Pain, Anesthesia","enrollment":14},{"nctId":"NCT02838056","phase":"NA","title":"Early Detection of Epidural Onset by Temperature Change","status":"UNKNOWN","sponsor":"Taipei Medical University WanFang Hospital","startDate":"2017-02-21","conditions":"Early Confirmation of Epidural Catheterization","enrollment":40},{"nctId":"NCT01199458","phase":"PHASE4","title":"The Effect of an Opioid on the Lower Esophageal Sphincter During Anesthesia Induction","status":"COMPLETED","sponsor":"Region Örebro County","startDate":"2010-09","conditions":"Lower Esophageal Sphincter","enrollment":17},{"nctId":"NCT02358057","phase":"PHASE4","title":"Can we Get Conscious Sedation by Combining Dexmedetomidine With Alfentanil?","status":"COMPLETED","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2015-02","conditions":"Procedural Sedation","enrollment":40},{"nctId":"NCT01805726","phase":"PHASE3","title":"Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil","status":"COMPLETED","sponsor":"Saint-Joseph University","startDate":"2013-02","conditions":"Bronchoscopy, Conscious Sedation","enrollment":162},{"nctId":"NCT01235637","phase":"PHASE3","title":"Alfentanil Versus Sufentanil for Pain in Children During for Tracheal Suction","status":"COMPLETED","sponsor":"University Hospital, Grenoble","startDate":"2010-06","conditions":"Child Comfort, Morphine, Intensive Care Units","enrollment":40},{"nctId":"NCT01464489","phase":"NA","title":"Intubation Time With Low Dose Rocuronium","status":"COMPLETED","sponsor":"Gachon University Gil Medical Center","startDate":"2011-05","conditions":"Intubation; Difficult","enrollment":44},{"nctId":"NCT01289327","phase":"NA","title":"Propofol Versus Midazolam+Alfentanil for Sedation During Bronchoscopy: Comparison by Cutaneous Carbon Dioxide Tension","status":"COMPLETED","sponsor":"Rabin Medical Center","startDate":"2010-04","conditions":"Lung Disease","enrollment":115}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ANAPHYLACTIC SHOCK"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Alfentanil Hydrochloride Injection","genericName":"Alfentanil Hydrochloride Injection","companyName":"The First Affiliated Hospital of Xinxiang Medical College","companyId":"the-first-affiliated-hospital-of-xinxiang-medical-college","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alfentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Analgesia and sedation during anesthesia, Acute pain management in perioperative settings, Sedation in intensive care units.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}