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Low dose of alfentanil hydrochloride
Low dose of alfentanil hydrochloride is a Opioid agonist Small molecule drug developed by University Hospital, Ghent. It is currently FDA-approved for Anesthesia induction and maintenance, Sedation and analgesia during surgical and diagnostic procedures, Perioperative pain management.
Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation.
Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. Used for Analgesia and sedation during anesthesia and perioperative procedures, Short-duration pain relief in acute care settings.
At a glance
| Generic name | Low dose of alfentanil hydrochloride |
|---|---|
| Sponsor | University Hospital, Ghent |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Analgesia |
| Phase | FDA-approved |
Mechanism of action
Alfentanil is a rapid-onset, short-acting opioid that activates mu opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing analgesia. At low doses, it is used for anesthesia induction, sedation during procedures, and perioperative pain management. Its short duration of action and rapid onset make it suitable for acute care settings where quick titration is needed.
Approved indications
- Anesthesia induction and maintenance
- Sedation and analgesia during surgical and diagnostic procedures
- Perioperative pain management
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Chest wall rigidity
- Dizziness
Key clinical trials
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols (PHASE4)
- Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP) (PHASE4)
- Intubation Time With Low Dose Rocuronium (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Low dose of alfentanil hydrochloride CI brief — competitive landscape report
- Low dose of alfentanil hydrochloride updates RSS · CI watch RSS
- University Hospital, Ghent portfolio CI
Frequently asked questions about Low dose of alfentanil hydrochloride
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Related
- Drug class: All Opioid agonist drugs
- Target: All drugs targeting Mu (μ) opioid receptor
- Manufacturer: University Hospital, Ghent — full pipeline
- Therapeutic area: All drugs in Anesthesia/Analgesia
- Indication: Drugs for Anesthesia induction and maintenance
- Indication: Drugs for Sedation and analgesia during surgical and diagnostic procedures
- Indication: Drugs for Perioperative pain management
- Compare: Low dose of alfentanil hydrochloride vs similar drugs
- Pricing: Low dose of alfentanil hydrochloride cost, discount & access