{"id":"low-dose-of-alfentanil-hydrochloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Chest wall rigidity"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alfentanil is a rapid-onset, short-acting opioid that activates mu opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing analgesia. At low doses, it is used for anesthesia induction, sedation during procedures, and perioperative pain management. Its short duration of action and rapid onset make it suitable for acute care settings where quick titration is needed.","oneSentence":"Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:26.068Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance"},{"name":"Sedation and analgesia during surgical and diagnostic procedures"},{"name":"Perioperative pain management"}]},"trialDetails":[{"nctId":"NCT07211828","phase":"NA","title":"EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives","status":"RECRUITING","sponsor":"Chi Kwan Fung","startDate":"2025-10-10","conditions":"Sedation and Analgesia, Cholangiopancreatography, Endoscopic Retrograde, Anesthesia, General","enrollment":20},{"nctId":"NCT00742807","phase":"PHASE4","title":"Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols","status":"WITHDRAWN","sponsor":"University Hospital, Ghent","startDate":"2008-08","conditions":"Pain","enrollment":""},{"nctId":"NCT01350037","phase":"PHASE4","title":"Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP)","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2009-06","conditions":"Biliary Tract Diseases, Pancreatic Diseases","enrollment":81},{"nctId":"NCT01464489","phase":"NA","title":"Intubation Time With Low Dose Rocuronium","status":"COMPLETED","sponsor":"Gachon University Gil Medical Center","startDate":"2011-05","conditions":"Intubation; Difficult","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Low dose of alfentanil hydrochloride","genericName":"Low dose of alfentanil hydrochloride","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. Used for Analgesia and sedation during anesthesia and perioperative procedures, Short-duration pain relief in acute care settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}