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Opioid administration morphine
Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and modulate emotional responses to pain.
Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and modulate emotional responses to pain. Used for Moderate to severe acute pain, Moderate to severe chronic pain, Postoperative pain.
At a glance
| Generic name | Opioid administration morphine |
|---|---|
| Sponsor | KK Women's and Children's Hospital |
| Drug class | Opioid agonist |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Morphine is a mu-opioid receptor agonist that crosses the blood-brain barrier and acts on opioid receptors in the brain, spinal cord, and peripheral tissues. This binding inhibits the transmission of pain signals and produces analgesia, sedation, and euphoria. It is commonly used for moderate to severe acute and chronic pain management.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
- Postoperative pain
Common side effects
- Respiratory depression
- Constipation
- Nausea and vomiting
- Drowsiness and sedation
- Dizziness
- Pruritus
- Dependence and tolerance
Key clinical trials
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty (PHASE4)
- Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use (PHASE1)
- Effectiveness of Percutaneous Neuromodulation vs Pharmacological Treatment in Cancer Patients With Anterior Knee Pain (NA)
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine (PHASE4)
- Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Opioid administration morphine CI brief — competitive landscape report
- Opioid administration morphine updates RSS · CI watch RSS
- KK Women's and Children's Hospital portfolio CI