{"id":"opioid-administration-morphine","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Drowsiness and sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Dependence and tolerance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that crosses the blood-brain barrier and acts on opioid receptors in the brain, spinal cord, and peripheral tissues. This binding inhibits the transmission of pain signals and produces analgesia, sedation, and euphoria. It is commonly used for moderate to severe acute and chronic pain management.","oneSentence":"Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and modulate emotional responses to pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:43.023Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Moderate to severe chronic pain"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT05461092","phase":"EARLY_PHASE1","title":"Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion","status":"RECRUITING","sponsor":"University of Iowa","startDate":"2024-01-01","conditions":"Delirium, Pain, Back, Spinal Fusion","enrollment":50},{"nctId":"NCT05731973","phase":"NA","title":"Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum","status":"COMPLETED","sponsor":"Zuyderland Medisch Centrum","startDate":"2023-12-08","conditions":"Pectus Excavatum, Funnel Chest","enrollment":50},{"nctId":"NCT07423650","phase":"PHASE4","title":"Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy","status":"RECRUITING","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2026-03","conditions":"Pancreatoduodenectomy, Pain Management, Opioid Analgesia","enrollment":93},{"nctId":"NCT07153003","phase":"PHASE4","title":"Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty","status":"ENROLLING_BY_INVITATION","sponsor":"Mayo Clinic","startDate":"2026-02-02","conditions":"Post Operative Pain","enrollment":560},{"nctId":"NCT07218549","phase":"PHASE1","title":"Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use","status":"NOT_YET_RECRUITING","sponsor":"Christopher D. Verrico","startDate":"2026-05-01","conditions":"Opioid Use, Substance Use Disorders, Opioid Analgesia","enrollment":72},{"nctId":"NCT06240390","phase":"NA","title":"Effectiveness of Percutaneous Neuromodulation vs Pharmacological Treatment in Cancer Patients With Anterior Knee Pain","status":"WITHDRAWN","sponsor":"Universidad Europea de Canarias","startDate":"2024-05-01","conditions":"Pain Cancer","enrollment":""},{"nctId":"NCT06784180","phase":"PHASE4","title":"Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine","status":"WITHDRAWN","sponsor":"University of North Carolina, Chapel Hill","startDate":"2026-02","conditions":"Opioid Use Disorder","enrollment":""},{"nctId":"NCT04772222","phase":"PHASE2","title":"Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)","status":"COMPLETED","sponsor":"University of Utah","startDate":"2022-06-20","conditions":"Hypoxic-Ischemic Encephalopathy, Pain","enrollment":50},{"nctId":"NCT06671002","phase":"PHASE4","title":"Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2025-01-10","conditions":"Surgery, Pain, Post Operative","enrollment":900},{"nctId":"NCT02381717","phase":"NA","title":"Ultrasound Guided Femoral Nerve Block","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2015-08","conditions":"Hip Fracture","enrollment":44},{"nctId":"NCT05257941","phase":"PHASE1, PHASE2","title":"ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery","status":"TERMINATED","sponsor":"Indiana University","startDate":"2022-01-27","conditions":"Surgery","enrollment":116},{"nctId":"NCT07059429","phase":"NA","title":"Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty","status":"COMPLETED","sponsor":"State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia","startDate":"2025-07-01","conditions":"Knee Arthroplasty, Postoperative Pain, Pain Management","enrollment":100},{"nctId":"NCT07278375","phase":"","title":"Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome","status":"RECRUITING","sponsor":"HELP for NOWS Consortium","startDate":"2025-12-09","conditions":"Neonatal Opioid Withdrawal Syndrome","enrollment":796},{"nctId":"NCT07425678","phase":"PHASE4","title":"Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2025-01-01","conditions":"Supratentorial Tumors","enrollment":62},{"nctId":"NCT04188418","phase":"PHASE3","title":"Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-10-23","conditions":"Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm","enrollment":150},{"nctId":"NCT07413731","phase":"","title":"Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation","status":"RECRUITING","sponsor":"Brai²n","startDate":"2025-02-03","conditions":"Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation, Neurophysiological Sensitivity to Spinal Cord Stimulation","enrollment":50},{"nctId":"NCT03257319","phase":"PHASE3","title":"Inhaled vs IV Opioid Dosing for the Initial Treatment of Severe Acute Pain in the Emergency Department","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2017-09-19","conditions":"Pain, Acute, Emergencies, Morphine","enrollment":226},{"nctId":"NCT02824276","phase":"PHASE1","title":"Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2017-01-06","conditions":"Low Back Pain","enrollment":35},{"nctId":"NCT04218409","phase":"EARLY_PHASE1","title":"Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination","status":"RECRUITING","sponsor":"University of Florida","startDate":"2021-09-02","conditions":"Pain","enrollment":45},{"nctId":"NCT04291599","phase":"PHASE2","title":"Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid","status":"TERMINATED","sponsor":"Boston Children's Hospital","startDate":"2022-03-15","conditions":"Acute Pancreatitis","enrollment":23},{"nctId":"NCT03756961","phase":"NA","title":"Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery","status":"RECRUITING","sponsor":"Göteborg University","startDate":"2019-05-01","conditions":"Obesity, Pain, Postoperative","enrollment":220},{"nctId":"NCT05129020","phase":"NA","title":"Neurostimulation to Improve NOWS Outcomes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Spark Biomedical, Inc.","startDate":"2022-07-27","conditions":"Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome","enrollment":52},{"nctId":"NCT05006079","phase":"PHASE2","title":"Opioid/Benzodiazepine Polydrug Abuse: Aim 3","status":"RECRUITING","sponsor":"Wayne State University","startDate":"2024-03-13","conditions":"Opioid Abuse, Benzodiazepine Abuse, Polysubstance Abuse","enrollment":24},{"nctId":"NCT07253610","phase":"NA","title":"Effect of Bilateral Rectointercostal Fascial Plane Block on Postoperative Pain After Laparoscopic Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Samsun University","startDate":"2025-11-01","conditions":"Pain, Postoperative, Obesity, Morbid, Laparoscopic Sleeve Gastrectomy (LSG)","enrollment":56},{"nctId":"NCT04296305","phase":"PHASE4","title":"Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-09-10","conditions":"Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm","enrollment":84},{"nctId":"NCT07296770","phase":"PHASE3","title":"An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery","enrollment":126},{"nctId":"NCT05673486","phase":"NA","title":"Regional Anesthesia by PENG-Block in Emergency Department","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","startDate":"2023-03-31","conditions":"Hip Fractures","enrollment":36},{"nctId":"NCT06576830","phase":"PHASE4","title":"Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia","status":"RECRUITING","sponsor":"Duke University","startDate":"2024-11-21","conditions":"Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis","enrollment":440},{"nctId":"NCT06505187","phase":"PHASE2","title":"Celecoxib for ENT Pain Management","status":"RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2025-02-28","conditions":"Parotidectomy","enrollment":84},{"nctId":"NCT05008926","phase":"PHASE3","title":"The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients","status":"RECRUITING","sponsor":"University Hospital, Brest","startDate":"2022-03-15","conditions":"Brain Injuries","enrollment":370},{"nctId":"NCT06868589","phase":"PHASE4","title":"Reducing Pain With Methadone and Ketamine in Liver Transplant","status":"RECRUITING","sponsor":"Lahey Clinic","startDate":"2025-06-30","conditions":"Liver Transplantation","enrollment":50},{"nctId":"NCT07229495","phase":"PHASE4","title":"Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery","status":"NOT_YET_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2026-01-01","conditions":"Scoliosis; Adolescence, Pain After Surgery, Analgesia, Patient-controlled","enrollment":171},{"nctId":"NCT01681264","phase":"PHASE4","title":"Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2014-09","conditions":"Chronic Pain","enrollment":200},{"nctId":"NCT06442566","phase":"PHASE1, PHASE2","title":"ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2024-08-12","conditions":"Opioid Withdrawal, Chronic Pain","enrollment":240},{"nctId":"NCT03958474","phase":"EARLY_PHASE1","title":"Neurobehavioral Mechanisms of Choice in Opioid Use Disorder","status":"COMPLETED","sponsor":"Joshua A. Lile, Ph.D.","startDate":"2019-08-16","conditions":"Opioid Use Disorder","enrollment":12},{"nctId":"NCT06940570","phase":"PHASE3","title":"Methadone as an Alternative Treatment for Children Underdoing HSCT","status":"SUSPENDED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2028-01-01","conditions":"Leukemia, Aplastic Anemia, Bone Marrow Failure Syndromes","enrollment":60},{"nctId":"NCT05722002","phase":"PHASE4","title":"Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2023-02-06","conditions":"Surgery, Pain, Postoperative","enrollment":900},{"nctId":"NCT07207304","phase":"NA","title":"Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes","status":"COMPLETED","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2022-02-03","conditions":"Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation, Anesthesia","enrollment":153},{"nctId":"NCT06047834","phase":"PHASE2","title":"Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids","status":"ACTIVE_NOT_RECRUITING","sponsor":"BioCorRx Pharmaceuticals Inc","startDate":"2023-10-02","conditions":"Opioid Withdrawal (Disorder)","enrollment":24},{"nctId":"NCT00210158","phase":"PHASE2","title":"Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment","status":"COMPLETED","sponsor":"Institut Bergonié","startDate":"2005-01-01","conditions":"Chronic Pain","enrollment":39},{"nctId":"NCT05862792","phase":"","title":"Liposomal Bupivacaine and Transoral Robotic Surgery","status":"RECRUITING","sponsor":"Geisinger Clinic","startDate":"2023-06-01","conditions":"Oropharyngeal Cancer, Dysphagia, Oropharyngeal, Post Operative Pain","enrollment":80},{"nctId":"NCT05639712","phase":"PHASE4","title":"Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2022-12-13","conditions":"Opioid Use, Affective Symptoms","enrollment":1020},{"nctId":"NCT06935331","phase":"PHASE4","title":"Prospective Opioid-Free AIS Fusion","status":"NOT_YET_RECRUITING","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2025-08-15","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":58},{"nctId":"NCT03579446","phase":"EARLY_PHASE1","title":"Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer","status":"TERMINATED","sponsor":"M.D. Anderson Cancer Center","startDate":"2018-11-29","conditions":"Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm","enrollment":43},{"nctId":"NCT07077031","phase":"","title":"Comparison of Two Magnesium Sulfate Protocols in Opioid-Free Anesthesia for Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital HM Nou Delfos","startDate":"2022-06-01","conditions":"Postoperative Pain, Obesity, Bariatric Surgery","enrollment":110},{"nctId":"NCT03651804","phase":"PHASE4","title":"Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures","status":"WITHDRAWN","sponsor":"University of California, Davis","startDate":"2019-04-10","conditions":"Vertebral Compression Fracture, Facet Joint Pain","enrollment":""},{"nctId":"NCT06404983","phase":"NA","title":"Opioid-free Anaesthesia in Breast Cancer Surgery","status":"RECRUITING","sponsor":"University of Ioannina","startDate":"2022-12-28","conditions":"Breast Cancer, Anesthesia, Pain, Postoperative","enrollment":200},{"nctId":"NCT04940689","phase":"PHASE3","title":"Opioid-Free Anesthesia in Cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2021-07-22","conditions":"Anesthesia","enrollment":268},{"nctId":"NCT05470465","phase":"PHASE1","title":"Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation","status":"COMPLETED","sponsor":"Food and Drug Administration (FDA)","startDate":"2022-09-01","conditions":"Hypercapnia, Ventilatory Depression","enrollment":27},{"nctId":"NCT04785768","phase":"PHASE3","title":"IV PCA With or Without Continuous Dose vs Oral Opioid to Maintain Analgesia for Severe Cancer Pain After Successful Titration","status":"COMPLETED","sponsor":"Fujian Cancer Hospital","startDate":"2021-07-01","conditions":"Cancer Pain","enrollment":1372},{"nctId":"NCT06344169","phase":"PHASE2, PHASE3","title":"Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section","status":"RECRUITING","sponsor":"Dalin Tzu Chi General Hospital","startDate":"2024-05-06","conditions":"Postsurgical Pain, Cesarean Section, Chronic Post-surgical Pain","enrollment":120},{"nctId":"NCT05761860","phase":"EARLY_PHASE1","title":"The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults","status":"RECRUITING","sponsor":"University of Florida","startDate":"2023-09-12","conditions":"Pain","enrollment":45},{"nctId":"NCT06929611","phase":"NA","title":"Analgesic Requirements for Lumbar Fixation With General Anaesthesia Versus Continuous Caudal Epidural","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-01-15","conditions":"Analgesia","enrollment":60},{"nctId":"NCT06774274","phase":"PHASE4","title":"Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.","status":"RECRUITING","sponsor":"Universidad de Antioquia","startDate":"2025-03-01","conditions":"Pain, Postoperative, Opioid Use, Major Surgery","enrollment":120},{"nctId":"NCT03705559","phase":"PHASE1","title":"Opioid and Cannabinoid Interactions","status":"COMPLETED","sponsor":"Shanna Babalonis, PhD","startDate":"2019-06-21","conditions":"Marijuana Usage, Opioid Use","enrollment":10},{"nctId":"NCT04659317","phase":"PHASE3","title":"Opioid-Free Orthopaedics","status":"RECRUITING","sponsor":"Emory University","startDate":"2020-12-11","conditions":"Pain, Pain, Postoperative","enrollment":80},{"nctId":"NCT06917118","phase":"NA","title":"Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial","status":"NOT_YET_RECRUITING","sponsor":"University of Puerto Rico","startDate":"2025-05-01","conditions":"Pain Management","enrollment":100},{"nctId":"NCT05740657","phase":"","title":"Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2022-12-06","conditions":"Opioid Use, Unspecified","enrollment":150},{"nctId":"NCT06897917","phase":"PHASE4","title":"Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain","status":"NOT_YET_RECRUITING","sponsor":"Henan Cancer Hospital","startDate":"2025-04","conditions":"Opioid-Induced Constipation, Pain Cancer","enrollment":203},{"nctId":"NCT06406400","phase":"PHASE1","title":"Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).","status":"TERMINATED","sponsor":"AstraZeneca","startDate":"2024-05-13","conditions":"Opioid Use Disorder","enrollment":15},{"nctId":"NCT06315920","phase":"PHASE3","title":"Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department","status":"NOT_YET_RECRUITING","sponsor":"Oman Medical Speciality Board","startDate":"2026-05-01","conditions":"Sickle-Cell Disease with Crisis","enrollment":226},{"nctId":"NCT04214834","phase":"PHASE3","title":"Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program","startDate":"2020-09-28","conditions":"Neonatal Opioid Withdrawal Syndrome","enrollment":189},{"nctId":"NCT06595329","phase":"PHASE1","title":"Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy","status":"RECRUITING","sponsor":"University Hospital of Split","startDate":"2025-01-15","conditions":"Pain, Renal Cancer, Surgical Procedure, Unspecified","enrollment":40},{"nctId":"NCT06340932","phase":"","title":"Impact of Opioid Avoidance Protocol for ACL Reconstruction","status":"COMPLETED","sponsor":"Matthew Varacallo","startDate":"2024-04-27","conditions":"ACL Tear, Post Operative Pain","enrollment":32},{"nctId":"NCT06864312","phase":"PHASE4","title":"Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery","status":"COMPLETED","sponsor":"University College Cork","startDate":"2023-10-16","conditions":"Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Ankle Fracture - Lateral Malleolus, Ankle Fracture - Medial Malleolus","enrollment":120},{"nctId":"NCT04761302","phase":"PHASE4","title":"Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures","status":"COMPLETED","sponsor":"University of Puerto Rico","startDate":"2021-04-18","conditions":"Femur Fracture, Tibial Fractures","enrollment":167},{"nctId":"NCT06764667","phase":"NA","title":"Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor","status":"RECRUITING","sponsor":"Indonesia University","startDate":"2025-02-10","conditions":"Laparoscopic Donor Nephrectomy, Perioperative Pain Management","enrollment":60},{"nctId":"NCT02651324","phase":"PHASE4","title":"Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis","status":"COMPLETED","sponsor":"Albany Medical College","startDate":"2013-05","conditions":"Idiopathic Scoliosis, Post-operative Pain","enrollment":50},{"nctId":"NCT04745520","phase":"NA","title":"Randomized Clinical Trial of Rib Fixation Versus Medical Analgesia in Uncomplicated Rib Fractures on Pain Control.","status":"TERMINATED","sponsor":"Benoît Bédat","startDate":"2021-03-12","conditions":"Rib Fractures","enrollment":102},{"nctId":"NCT06059339","phase":"NA","title":"Comparing Pericapsular Nerve Group Block with Lumbar Erector Spinae Plain Block in Total Hip Arthroplasty Surgery","status":"COMPLETED","sponsor":"Marmara University","startDate":"2023-04-22","conditions":"Postoperative Pain, Total Hip Arthroplasty","enrollment":66},{"nctId":"NCT06458400","phase":"PHASE4","title":"To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain","status":"COMPLETED","sponsor":"Yuwei Qiu","startDate":"2024-07-03","conditions":"Analgesia","enrollment":75},{"nctId":"NCT06750627","phase":"PHASE4","title":"Efficacy of Continuous Erector Spinae Plane Block to Reduce Postoperative Pain in Patients Undergoing Unilateral Thoracotomy","status":"NOT_YET_RECRUITING","sponsor":"Udayana University","startDate":"2025-01-01","conditions":"Continuous Erector Spinae Plane Block, Unilateral Thoracotomy","enrollment":30},{"nctId":"NCT04230681","phase":"EARLY_PHASE1","title":"Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2020-02-26","conditions":"Obstructive Sleep Apnea, Tonsillitis","enrollment":189},{"nctId":"NCT05463367","phase":"PHASE2","title":"Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Northwestern University","startDate":"2021-01-01","conditions":"Opioid Use, Opioid Dependence, Opioid-use Disorder","enrollment":60},{"nctId":"NCT04764825","phase":"PHASE4","title":"Methadone for Spinal Fusion Surgery.","status":"TERMINATED","sponsor":"University of Aarhus","startDate":"2021-02-26","conditions":"Pain, Postoperative, Back Pain, Opioid Use","enrollment":114},{"nctId":"NCT05117034","phase":"NA","title":"Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2022-02-16","conditions":"Pain, Postoperative, Anesthesia, Analgesia","enrollment":115},{"nctId":"NCT06463899","phase":"NA","title":"Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time","status":"RECRUITING","sponsor":"CHU de Reims","startDate":"2023-02-08","conditions":"Duration of Hospitalization in Intensive Care Unit","enrollment":114},{"nctId":"NCT06669650","phase":"PHASE4","title":"Personalized Post-Operative Pain Management","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Tennessee Graduate School of Medicine","startDate":"2024-09-25","conditions":"Persistent Post Operative Opioid Use, Post-surgical Pain","enrollment":208},{"nctId":"NCT06511232","phase":"PHASE4","title":"Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction","status":"RECRUITING","sponsor":"The Methodist Hospital Research Institute","startDate":"2024-08-19","conditions":"Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture","enrollment":84},{"nctId":"NCT04172220","phase":"NA","title":"Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?","status":"COMPLETED","sponsor":"Centro di Riferimento Oncologico - Aviano","startDate":"2019-10-31","conditions":"Breast Cancer Female","enrollment":68},{"nctId":"NCT02804022","phase":"PHASE2","title":"Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia","status":"ACTIVE_NOT_RECRUITING","sponsor":"KK Women's and Children's Hospital","startDate":"2016-12-29","conditions":"Respiratory Depression","enrollment":20},{"nctId":"NCT06609993","phase":"NA","title":"AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair","status":"COMPLETED","sponsor":"Michał Stasiowski","startDate":"2017-12-12","conditions":"Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":75},{"nctId":"NCT05043766","phase":"PHASE1","title":"Evaluation of Oral PF614 Relative to OxyContin (PF614-102)","status":"COMPLETED","sponsor":"Ensysce Biosciences","startDate":"2021-09-08","conditions":"Healthy Volunteers","enrollment":84},{"nctId":"NCT03859024","phase":"PHASE4","title":"Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2019-03-22","conditions":"Pain, Postoperative, Urethral Stricture","enrollment":48},{"nctId":"NCT03467750","phase":"PHASE4","title":"Effect of Ketorolac on Post Adenotonsillectomy Pain","status":"COMPLETED","sponsor":"Emory University","startDate":"2018-07-19","conditions":"Obstructive Sleep Apnea","enrollment":63},{"nctId":"NCT04791761","phase":"PHASE1, PHASE2","title":"Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy","status":"TERMINATED","sponsor":"David Chi, MD","startDate":"2021-04-13","conditions":"Adenotonsillectomy, Post-operative Analgesia, Opioid Use","enrollment":73},{"nctId":"NCT03889418","phase":"NA","title":"Opioid Treatment and Recovery Through a Safe Pain Management Program","status":"COMPLETED","sponsor":"Ochsner Health System","startDate":"2019-04-01","conditions":"Depression, Opioid Use, Chronic Pain","enrollment":490},{"nctId":"NCT06485817","phase":"NA","title":"How Stress Alters Opioid Drug Effects","status":"COMPLETED","sponsor":"University of Oslo","startDate":"2021-11-15","conditions":"Motivation, Drug Effect, Stress Reaction","enrollment":80},{"nctId":"NCT04234191","phase":"PHASE2","title":"Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use Disorder","status":"RECRUITING","sponsor":"University of British Columbia","startDate":"2021-08-18","conditions":"Opioid Use Disorder","enrollment":50},{"nctId":"NCT05375916","phase":"NA","title":"Comparison of Short-term Sustained-release Opioid in Open Abdominal Urologic Surgeries","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2022-05-03","conditions":"Pain, Acute, Opioid Use","enrollment":80},{"nctId":"NCT02929589","phase":"PHASE3","title":"Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy","status":"TERMINATED","sponsor":"Mike O'Callaghan Military Hospital","startDate":"2018-07-05","conditions":"Pain, Hernia","enrollment":18},{"nctId":"NCT06258239","phase":"NA","title":"Influence of the Communication Between the Nursing Staff and the Patient on the Analgesic Treatment Effectiveness After Surgery","status":"UNKNOWN","sponsor":"University of Haifa","startDate":"2023-04-01","conditions":"Post-operative Pain","enrollment":100},{"nctId":"NCT03375216","phase":"NA","title":"Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering","status":"COMPLETED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2017-12-22","conditions":"Analgesic Drug Dependence, Sensory Deficit","enrollment":43},{"nctId":"NCT06216210","phase":"","title":"Assessing the Impact of Opioid-Free Anesthesia Using the Modified Mulimix Technique.","status":"COMPLETED","sponsor":"Zulekha Hospitals","startDate":"2022-04-22","conditions":"Opioid Use","enrollment":60},{"nctId":"NCT03700411","phase":"PHASE4","title":"Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery","status":"COMPLETED","sponsor":"The Institute of Molecular and Translational Medicine, Czech Republic","startDate":"2019-01-07","conditions":"Colorectal Cancer, Circulating Tumor Cell","enrollment":125},{"nctId":"NCT05515718","phase":"NA","title":"Effect of the Early Ultrasound-guided Femoral Nerve Block Performed by Emergency Physicians on Pre-operative Opioids Usage in Patients With Proximal Femoral Fractures","status":"COMPLETED","sponsor":"Fondation Hôpital Saint-Joseph","startDate":"2022-09-07","conditions":"Femoral Fracture, Femoral Nerve Block","enrollment":35},{"nctId":"NCT05372133","phase":"NA","title":"Split Scripts for Pediatric Supracondylar Fracture Repairs","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2022-08-11","conditions":"Pain, Postoperative","enrollment":175},{"nctId":"NCT04987372","phase":"PHASE4","title":"Multimodal Versus Opioid aNalgesia in carDiAc Surgery","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2019-01-21","conditions":"Postoperative Pain, Postoperative Delirium","enrollment":100},{"nctId":"NCT04470050","phase":"PHASE1, PHASE2","title":"Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal","status":"COMPLETED","sponsor":"BioXcel Therapeutics Inc","startDate":"2020-06-09","conditions":"Opioid Withdrawal","enrollment":225},{"nctId":"NCT04285853","phase":"PHASE4","title":"Are Opioids Needed After ACL Reconstruction","status":"COMPLETED","sponsor":"Emory University","startDate":"2020-09-16","conditions":"Anterior Cruciate Ligament Rupture","enrollment":98}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":45,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Opioid administration morphine","genericName":"Opioid administration morphine","companyName":"KK Women's and Children's Hospital","companyId":"kk-women-s-and-children-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and modulate emotional responses to pain. Used for Moderate to severe acute pain, Moderate to severe chronic pain, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}