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Fentanyl intranasal
Fentanyl is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
Fentanyl is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute pain management in pediatric patients, Procedural sedation and analgesia in children.
At a glance
| Generic name | Fentanyl intranasal |
|---|---|
| Also known as | Fentanyl Sintetica |
| Sponsor | University Children's Hospital, Zurich |
| Drug class | Opioid agonist |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing rapid analgesia. The intranasal formulation allows for non-invasive, rapid absorption through nasal mucosa, providing faster onset than oral routes while avoiding first-pass hepatic metabolism. This route is particularly useful in pediatric populations for acute pain management and procedural sedation.
Approved indications
- Acute pain management in pediatric patients
- Procedural sedation and analgesia in children
Common side effects
- Respiratory depression
- Sedation
- Nausea
- Dizziness
- Headache
Key clinical trials
- Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (PHASE3)
- Blocking Sphenopalatine Ganglion by Intranasal Lidocaine Spray in Partial Turbinectomy Surgeries (PHASE3)
- Pain Control Alternatives in Pediatric Patients With Distal Radius Fractures (PHASE3)
- Intranasal Versus Intravenous Fentanyl For Procedural Analgesia in Preterm Neonates (EARLY_PHASE1)
- Study Comparing Atomizerd Midazolam & Fentanyl and Dexmedomidine for Procedural Sedation in Adult and Pediatric Patient (2 to 60 Years Old) (NA)
- Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room (PHASE2)
- Pain Managment in Preterm Neonates (PHASE2, PHASE3)
- Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |