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Morphine and oxycodone
Morphine and oxycodone are opioid agonists that bind to mu opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
Morphine and oxycodone are opioid agonists that bind to mu opioid receptors in the central nervous system to reduce pain perception and provide analgesia. Used for Moderate to severe acute pain, Moderate to severe chronic pain, Cancer pain.
At a glance
| Generic name | Morphine and oxycodone |
|---|---|
| Sponsor | Ullevaal University Hospital |
| Drug class | Opioid agonist |
| Target | Mu opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Both drugs work by activating mu opioid receptors throughout the brain and spinal cord, which decreases the transmission and perception of pain signals. They also produce sedation and euphoria by affecting reward pathways. Oxycodone is a semi-synthetic derivative with similar potency to morphine but different pharmacokinetics, while morphine is the natural alkaloid standard.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
- Cancer pain
Common side effects
- Constipation
- Nausea
- Drowsiness/sedation
- Dizziness
- Respiratory depression
- Dependence/addiction
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty (PHASE4)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |