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Preoperative Methadone
Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to provide analgesia and sedation for preoperative use.
Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to provide analgesia and sedation for preoperative use. Used for Preoperative analgesia and sedation.
At a glance
| Generic name | Preoperative Methadone |
|---|---|
| Sponsor | University of Louisville |
| Drug class | Opioid agonist |
| Target | Mu opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Methadone acts as a full agonist at mu opioid receptors, producing analgesic and sedative effects through central nervous system depression. In the preoperative setting, it is used to reduce pain and anxiety prior to surgery. Methadone has a long half-life and slow onset, making it suitable for premedication protocols.
Approved indications
- Preoperative analgesia and sedation
Common side effects
- Respiratory depression
- Sedation
- Hypotension
- Nausea
- Dizziness
Key clinical trials
- An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service (PHASE3)
- Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study (PHASE4)
- Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB) (NA)
- Postoperative Oral Methadone After Major Spine Surgery; Safety, Feasibility and Efficacy in Prevention of Progression to Chronic Opioid Usage at 3 Months (PHASE2, PHASE3)
- Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA (PHASE4)
- Methadone Pharmacokinetics in End-stage Renal Disease
- Postoperative Opioid and Respiratory Depression in Opioid Naive and Chronic Opioid Patients
- Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Preoperative Methadone CI brief — competitive landscape report
- Preoperative Methadone updates RSS · CI watch RSS
- University of Louisville portfolio CI