Preoperative Methadone — Competitive Intelligence Brief

Preoperative Methadone (Preoperative Methadone) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid agonist. Area: Anesthesia/Perioperative Medicine.

marketed Opioid agonist Mu opioid receptor Anesthesia/Perioperative Medicine Small molecule

Target snapshot

Preoperative Methadone (Preoperative Methadone) — University of Louisville. Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to provide analgesia and sedation for preoperative use.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Preoperative Methadone TARGET	Preoperative Methadone	University of Louisville	marketed	Opioid agonist	Mu opioid receptor
NALBUPHINE HYDROCHLORIDE	NALBUPHINE HYDROCHLORIDE		marketed		kappa opioid receptors, mu opioid receptors	1979-01-01
Ropivacaine/Fentanyl	Ropivacaine/Fentanyl	National Institute for Tuberculosis and Lung Diseases, Poland	marketed	Local anesthetic with opioid analgesic combination	Voltage-gated sodium channels (ropivacaine); mu opioid receptor (fentanyl)
Acetaminophen-Hydrocodone	Acetaminophen-Hydrocodone	Le Bonheur Children's Hospital	marketed	Opioid analgesic combination	Mu opioid receptor (hydrocodone component); prostaglandin synthesis inhibition (acetaminophen component)
Bupivacaine-fentanyl elective group	Bupivacaine-fentanyl elective group	Conrad Arnfinn Bjørshol	marketed	Local anesthetic with opioid analgesic combination	Voltage-gated sodium channels (bupivacaine); mu opioid receptor (fentanyl)
Ibuprofen + Paracetamol + Codeine	Ibuprofen + Paracetamol + Codeine	Ullevaal University Hospital	marketed	Combination analgesic (NSAID + acetaminophen + opioid)	COX-1/COX-2 (ibuprofen, paracetamol); mu opioid receptor (codeine)
liquid oxycodone	liquid oxycodone	Boston Children's Hospital	marketed	Opioid analgesic	Mu opioid receptor (OPRM1)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid agonist class)

1. University of British Columbia · 3 drugs in this class
2. Ciusss de L'Est de l'Île de Montréal · 2 drugs in this class
3. Kaohsiung Veterans General Hospital. · 2 drugs in this class
4. Nycomed · 2 drugs in this class
5. Rigshospitalet, Denmark · 2 drugs in this class
6. University Hospital, Ghent · 2 drugs in this class
7. Fundación Universitaria de Ciencias de la Salud · 2 drugs in this class
8. Erasme University Hospital · 2 drugs in this class
9. Cephalon · 2 drugs in this class
10. Corporacion Parc Tauli · 1 drug in this class