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Ibuprofen + Paracetamol + Codeine
This combination reduces pain and fever through inhibition of prostaglandin synthesis (ibuprofen and paracetamol) while codeine provides additional analgesia via opioid receptor agonism.
This combination reduces pain and fever through inhibition of prostaglandin synthesis (ibuprofen and paracetamol) while codeine provides additional analgesia via opioid receptor agonism. Used for Moderate acute pain, Post-operative pain, Musculoskeletal pain.
At a glance
| Generic name | Ibuprofen + Paracetamol + Codeine |
|---|---|
| Also known as | Ibuprofen, ATC code: M01A E01, Paracetamol (Acetaminophen), ATC code: N02B E01, Codeine |
| Sponsor | Ullevaal University Hospital |
| Drug class | Combination analgesic (NSAID + acetaminophen + opioid) |
| Target | COX-1/COX-2 (ibuprofen, paracetamol); mu opioid receptor (codeine) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen and paracetamol are nonsteroidal anti-inflammatory drugs and analgesics that inhibit cyclooxygenase enzymes to reduce prostaglandin production, thereby decreasing pain and fever. Codeine is a weak opioid agonist that binds to mu opioid receptors in the central nervous system to enhance pain relief. The combination provides synergistic analgesic effects for moderate pain management.
Approved indications
- Moderate acute pain
- Post-operative pain
- Musculoskeletal pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Drowsiness
- Gastrointestinal upset
- Headache
Key clinical trials
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Reduced Opioid Prescription After Laparoscopic Hysterectomy (NA)
- Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial (PHASE2)
- Opioid Use After Laparoscopic Salpingectomy (PHASE4)
- NSAID Use After Robotic Partial Nephrectomy (PHASE2)
- Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction (PHASE1)
- Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen + Paracetamol + Codeine CI brief — competitive landscape report
- Ibuprofen + Paracetamol + Codeine updates RSS · CI watch RSS
- Ullevaal University Hospital portfolio CI