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Ropivacaine/Fentanyl
Ropivacaine is a local anesthetic that blocks sodium channels in nerve membranes, while fentanyl is an opioid agonist that binds to mu opioid receptors to provide analgesia.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve membranes, while fentanyl is an opioid agonist that binds to mu opioid receptors to provide analgesia. Used for Regional anesthesia and analgesia for surgical procedures, Postoperative pain management.
At a glance
| Generic name | Ropivacaine/Fentanyl |
|---|---|
| Also known as | ROPIVACAINE HYDROCHLORIDE 10 mg/ml |
| Sponsor | National Institute for Tuberculosis and Lung Diseases, Poland |
| Drug class | Local anesthetic with opioid analgesic combination |
| Target | Voltage-gated sodium channels (ropivacaine); mu opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly inhibits sodium influx into nerve fibers, preventing depolarization and blocking pain signal transmission. Fentanyl enhances this effect by activating mu opioid receptors in the central and peripheral nervous system, providing additional analgesia and potentially reducing the required local anesthetic dose. This combination is used for regional anesthesia and analgesia.
Approved indications
- Regional anesthesia and analgesia for surgical procedures
- Postoperative pain management
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Respiratory depression
- Neurological toxicity (at high doses)
Key clinical trials
- Comparing PIEB and CEI for Labor Pain Relief (NA)
- Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection (NA)
- Ropivacaine and Fentanyl for Labor Epidural Initiation (PHASE3)
- Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery. (PHASE3)
- EOI Block in Otoplasty With Rib Cartilage Graft (NA)
- Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies (NA)
- SFIB vs PENG Block in the Anesthesia for Total Hip Replacement (NA)
- Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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