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Bupivacaine-fentanyl elective group
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, while fentanyl is an opioid agonist that binds to mu opioid receptors to provide analgesia, together delivering regional anesthesia and analgesia for elective procedures.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, while fentanyl is an opioid agonist that binds to mu opioid receptors to provide analgesia, together delivering regional anesthesia and analgesia for elective procedures. Used for Regional anesthesia and analgesia for elective surgical procedures.
At a glance
| Generic name | Bupivacaine-fentanyl elective group |
|---|---|
| Sponsor | Conrad Arnfinn Bjørshol |
| Drug class | Local anesthetic with opioid analgesic combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes, preventing depolarization and blocking pain signal transmission in the targeted region. Fentanyl enhances analgesia by activating mu opioid receptors in the central and peripheral nervous system. This combination provides both local anesthetic blockade and systemic opioid analgesia for perioperative pain management.
Approved indications
- Regional anesthesia and analgesia for elective surgical procedures
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Respiratory depression
- Dizziness
- Headache
Key clinical trials
- Effect of a 20% Reduction in Hyperbaric Bupivacaine Dose on High Spinal Block Incidence in Cesarean Delivery: A Risk-Stratified Randomized Controlled Trial. (PHASE4)
- Comparison Between Intravenous Hydrocortisone and Ondansetron in Prevention of Post Spinal Anesthesia Hypotension (NA)
- Quadratus Lumborum in Cesarean Section Trial (NA)
- Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section (NA)
- Postdural Puncture Headache After Spinal Anesthesia for Cesarean Section (NA)
- Comparison Between Hyperbaric Bupivacaine With Fentanyl vs. Hyperbaric Bupivacaine With Dexmedetomidine in Reducing Visceral Pain During Cesarean Delivery Under Spinal Anaesthesia (PHASE4)
- Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery (NA)
- Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine-fentanyl elective group CI brief — competitive landscape report
- Bupivacaine-fentanyl elective group updates RSS · CI watch RSS
- Conrad Arnfinn Bjørshol portfolio CI