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IV opioid
IV opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.
IV opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia. Used for Acute moderate-to-severe pain (postoperative, trauma, acute medical conditions), Chronic severe pain (cancer pain, palliative care).
At a glance
| Generic name | IV opioid |
|---|---|
| Also known as | Discretionary care |
| Sponsor | Montefiore Medical Center |
| Drug class | Opioid agonist |
| Target | Mu opioid receptor (primary); delta and kappa opioid receptors (secondary) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Opioids are agonists at mu, delta, and kappa opioid receptors, with mu-receptor activation being the primary mechanism for analgesia. By binding to these G-protein coupled receptors, they inhibit neurotransmitter release and hyperpolarize neurons, reducing pain signal transmission. IV administration provides rapid onset and is used for acute, moderate-to-severe pain management in clinical settings.
Approved indications
- Acute moderate-to-severe pain (postoperative, trauma, acute medical conditions)
- Chronic severe pain (cancer pain, palliative care)
Common side effects
- Respiratory depression
- Sedation
- Nausea and vomiting
- Constipation
- Hypotension
- Pruritus
- Dependence and tolerance
Key clinical trials
- Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections (PHASE2)
- Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients (PHASE4)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- Erector Spinae Plane Block for Pain Control After Open Abdominal Surgery (NA)
- Symptom-inhibited Fentanyl Induction (PHASE4)
- Postoperative Pain Will be Compared in Cholecystectomy Patients: Half Receiving TAP Block and Half Without it. (NA)
- Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |