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IV administration provides rapid onset and is used for acute, moderate-to-severe pain management in clinical settings.","oneSentence":"IV opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:58.030Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute moderate-to-severe pain (postoperative, trauma, acute medical conditions)"},{"name":"Chronic severe pain (cancer pain, palliative care)"}]},"trialDetails":[{"nctId":"NCT04677114","phase":"PHASE2","title":"Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections","status":"COMPLETED","sponsor":"Laura Fanucchi","startDate":"2021-03-16","conditions":"Drug Use, Opioid-use Disorder","enrollment":71},{"nctId":"NCT06903819","phase":"PHASE4","title":"Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma 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