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Remifentanil fixed
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation.
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Intravenous analgesia and sedation during general anesthesia and monitored anesthesia care, Acute postoperative pain management.
At a glance
| Generic name | Remifentanil fixed |
|---|---|
| Sponsor | Erasme University Hospital |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Analgesia |
| Phase | FDA-approved |
Mechanism of action
Remifentanil activates mu opioid receptors, which inhibit pain signal transmission and produce sedative effects. It is characterized by rapid onset and offset due to metabolism by non-specific plasma and tissue esterases, making it suitable for short procedures and intravenous anesthesia. The drug is commonly used in perioperative settings where quick reversibility is clinically advantageous.
Approved indications
- Intravenous analgesia and sedation during general anesthesia and monitored anesthesia care
- Acute postoperative pain management
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Muscle rigidity
- Nausea and vomiting
- Apnea
Key clinical trials
- Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio (PHASE4)
- A Study on Median Effective Concentration of Ciprofol Combined With Remifentanil Via Target-controlled Infusion for Inhibiting Tracheal Intubation Stimulation Under qNOX Index Monitoring (NA)
- Tranexamic Acid Dose and Remifentanil Titration in Septorhinoplasty
- Opioid-free Analgesia in Intensive Care Unit (PHASE4)
- Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS (NA)
- The Application of Pectoral Nerve II(PECS II)block in Breast Fibroadenoma Resection Surgery (NA)
- Intraoperative Nociception Monitoring with Medstorm, Medasense and Anspec-pro During Total Intravenous Anesthesia (NA)
- Effects of Analgesia Nociception Index (ANI)-Guided Analgesia on Postoperative Bowel Function. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Remifentanil fixed CI brief — competitive landscape report
- Remifentanil fixed updates RSS · CI watch RSS
- Erasme University Hospital portfolio CI