{"id":"remifentanil-fixed","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Muscle rigidity"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Apnea"}]},"_chembl":{"chemblId":"CHEMBL1201120","moleculeType":"Small molecule","molecularWeight":"412.91"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Remifentanil activates mu opioid receptors, which inhibit pain signal transmission and produce sedative effects. It is characterized by rapid onset and offset due to metabolism by non-specific plasma and tissue esterases, making it suitable for short procedures and intravenous anesthesia. The drug is commonly used in perioperative settings where quick reversibility is clinically advantageous.","oneSentence":"Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:36.468Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intravenous analgesia and sedation during general anesthesia and monitored anesthesia care"},{"name":"Acute postoperative pain management"}]},"trialDetails":[{"nctId":"NCT07479719","phase":"PHASE4","title":"Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2026-04","conditions":"Elderly, Surgery, Depth of Anesthesia","enrollment":200},{"nctId":"NCT07462949","phase":"NA","title":"A Study on Median Effective Concentration of Ciprofol Combined With Remifentanil Via Target-controlled Infusion for Inhibiting Tracheal Intubation Stimulation Under qNOX Index Monitoring","status":"ACTIVE_NOT_RECRUITING","sponsor":"Guangzhou General Hospital of Guangzhou Military Command","startDate":"2025-12-01","conditions":"Elective Surgery, Target Controlled Infusion (TCI), Noxious Stimuli","enrollment":70},{"nctId":"NCT07450794","phase":"","title":"Tranexamic Acid Dose and Remifentanil Titration in Septorhinoplasty","status":"NOT_YET_RECRUITING","sponsor":"Istinye University","startDate":"2026-03-05","conditions":"Anesthesiologist Workload","enrollment":90},{"nctId":"NCT05825560","phase":"PHASE4","title":"Opioid-free Analgesia in Intensive Care Unit","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2023-05-15","conditions":"Intubation","enrollment":50},{"nctId":"NCT06367218","phase":"NA","title":"Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2024-10-01","conditions":"Video-assisted Thoracoscopic Lung Surgery；Anesthesia","enrollment":480},{"nctId":"NCT06608810","phase":"NA","title":"The Application of Pectoral Nerve II(PECS II)block in Breast Fibroadenoma Resection Surgery","status":"COMPLETED","sponsor":"Inner Mongolia Baogang Hospital","startDate":"2023-07-30","conditions":"Breast Neoplasms","enrollment":90},{"nctId":"NCT04986163","phase":"NA","title":"Intraoperative Nociception Monitoring with Medstorm, Medasense and Anspec-pro During Total Intravenous Anesthesia","status":"TERMINATED","sponsor":"University Hospital, Ghent","startDate":"2021-02-03","conditions":"Pain Measurement","enrollment":70},{"nctId":"NCT05122078","phase":"NA","title":"Effects of Analgesia Nociception Index (ANI)-Guided Analgesia on Postoperative Bowel Function.","status":"RECRUITING","sponsor":"Gangnam Severance Hospital","startDate":"2021-11-29","conditions":"Postoperative Bowel Function Recovery","enrollment":80},{"nctId":"NCT06417645","phase":"PHASE4","title":"Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model","status":"RECRUITING","sponsor":"Universidad del Desarrollo","startDate":"2013-09-01","conditions":"Healthy, Surgery","enrollment":24},{"nctId":"NCT03143972","phase":"PHASE4","title":"Pharmacodynamic Interaction of REMI and DMED","status":"COMPLETED","sponsor":"University Medical Center Groningen","startDate":"2017-06-28","conditions":"Anesthesia","enrollment":30},{"nctId":"NCT05839366","phase":"PHASE3","title":"Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients","status":"UNKNOWN","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2023-05-31","conditions":"Septic Shock, Mechanical Ventilation Complication","enrollment":124},{"nctId":"NCT03117894","phase":"NA","title":"PECS-2 for Breast Surgery","status":"COMPLETED","sponsor":"Umeå University","startDate":"2017-05-23","conditions":"Breast Neoplasm Female, Regional Anesthesia, Anesthesia","enrollment":200},{"nctId":"NCT03324269","phase":"NA","title":"Evaluating the Predictive Value of the Nociception Level Index NOL","status":"COMPLETED","sponsor":"Université Libre de Bruxelles","startDate":"2017-10-01","conditions":"Pain, Anesthesia","enrollment":36},{"nctId":"NCT02400879","phase":"NA","title":"Remifentanil Anesthesia and Postoperative BIS in Cardiac Surgery","status":"COMPLETED","sponsor":"Konkuk University Medical Center","startDate":"2015-10","conditions":"Cardiovascular Disease","enrollment":38},{"nctId":"NCT04333992","phase":"NA","title":"Propofol Versus Sevoflurane on Acute Postoperative Pain","status":"COMPLETED","sponsor":"Yeungnam University College of Medicine","startDate":"2017-02-01","conditions":"Postoperative Pain","enrollment":48},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":"Postoperative Nausea and Vomiting","enrollment":27034},{"nctId":"NCT02543580","phase":"NA","title":"TEAS-induced Analgesia: Dual vs Single Acupoints","status":"COMPLETED","sponsor":"Xijing Hospital","startDate":"2015-07","conditions":"Postoperative, Acute Pain, Chronic Pain","enrollment":153},{"nctId":"NCT02884310","phase":"PHASE4","title":"Interest of a Tetanus Test at a Fixed Remifentanil Concentration Before Laryngoscopy and Skin Incision","status":"COMPLETED","sponsor":"Erasme University Hospital","startDate":"2013-01","conditions":"Intravenous Anesthetic Agent Overdose","enrollment":48},{"nctId":"NCT01542099","phase":"NA","title":"The EC50 of Remifentanil Blunting Hemodynamic Response to Double Lumen Tube Intubation","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2011-11","conditions":"Hemodynamic Responses During Tracheal Intubation","enrollment":80},{"nctId":"NCT02283866","phase":"NA","title":"Bispectral Index-Guided Versus Fixed Dose Administration of Desflurane During Balanced Anesthesia With Remifentanil","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-06","conditions":"Stabilizing Hypnotic Depth and Vital Sign During Balanced Anesthesia","enrollment":48},{"nctId":"NCT01950702","phase":"NA","title":"Laryngoscope Asssited Lightwand Intubation","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2013-09","conditions":"Cervical Spine Surgery","enrollment":168},{"nctId":"NCT02169843","phase":"PHASE4","title":"Small Doses of Dexmedetomidine for Emergence Agitation","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-05","conditions":"Emergence Agitation","enrollment":80},{"nctId":"NCT02102139","phase":"PHASE4","title":"Preop Dexmedetomidine Attenuates Haemodynamic Responses to Hydrodissection","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2012-05","conditions":"Robotic Thyroidectomy","enrollment":41},{"nctId":"NCT01921283","phase":"NA","title":"Monitored Anesthesia Care With Propofol Plus Remifentanil During Endoscopic Submucosal Dissection: Evaluation of Bispectral Index Monitoring","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2011-09","conditions":"Early Gastric Cancer","enrollment":180},{"nctId":"NCT00522587","phase":"PHASE2","title":"Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2008-04","conditions":"Anesthesia","enrollment":40},{"nctId":"NCT01489137","phase":"NA","title":"The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2011-11","conditions":"Brain Tumor, AVM, ICH","enrollment":50},{"nctId":"NCT01103193","phase":"PHASE4","title":"Nitrous Oxide - Sevoflurane-Remifentanil Interaction","status":"TERMINATED","sponsor":"University Hospital, Ghent","startDate":"2010-02","conditions":"ASA Class I/II Patients Scheduled for Surgery Under General Anesthesia","enrollment":4}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":117,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Remifentanil fixed","genericName":"Remifentanil fixed","companyName":"Erasme University Hospital","companyId":"erasme-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Intravenous analgesia and sedation during general anesthesia and monitored anesthesia care, Acute postoperative pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}