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Methadone Treatment-As-Usual
Methadone is a mu-opioid receptor agonist that works by activating opioid receptors in the brain, reducing withdrawal symptoms and cravings in individuals with opioid use disorder.
Methadone is a mu-opioid receptor agonist that works by activating opioid receptors in the brain, reducing withdrawal symptoms and cravings in individuals with opioid use disorder. Used for Treatment of opioid use disorder.
At a glance
| Generic name | Methadone Treatment-As-Usual |
|---|---|
| Sponsor | Friends Research Institute, Inc. |
| Drug class | opioid agonist |
| Target | mu-opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Addiction |
| Phase | Phase 3 |
Mechanism of action
Methadone's mechanism of action involves binding to mu-opioid receptors, which are responsible for the euphoric effects of opioids. By activating these receptors, methadone helps to reduce the severity of withdrawal symptoms and cravings, making it easier for individuals to manage their opioid use disorder. Additionally, methadone's long half-life allows for once-daily dosing, which can improve adherence and reduce the risk of overdose.
Approved indications
- Treatment of opioid use disorder
Common side effects
- Dizziness
- Nausea
- Headache
- Fatigue
- Constipation
- Sedation
- Vomiting
- Abdominal pain
- Diarrhea
- Insomnia
Key clinical trials
- Remotely Observed Methadone Evaluation II (PHASE2)
- Divided or Single Exposure (DOSE) Study (PHASE2, PHASE3)
- An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service (PHASE3)
- Treating Polysubstance Use Using a Novel Digital Technology (PHASE3)
- EXHIT ENTRE Comparative Effectiveness Trial (PHASE2, PHASE3)
- NavSTAR Implementation Effectiveness Trial Across a Health System (NA)
- Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence (NA)
- MethaLoad Dose-Finding Study (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methadone Treatment-As-Usual CI brief — competitive landscape report
- Methadone Treatment-As-Usual updates RSS · CI watch RSS
- Friends Research Institute, Inc. portfolio CI