Who is sponsoring NCT05299515?

NCT05299515 is sponsored by University of Maryland, College Park.

What drugs are being tested in NCT05299515?

Interventions in NCT05299515: Peer-Delivered Behavioral Activation ("Peer Activate").

What condition does NCT05299515 study?

NCT05299515 studies Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use, Opioid Addiction, Treatment Adherence, Retention in Care.

Is NCT05299515 still recruiting?

NCT05299515 is currently completed. Last updated 27 October 2025.

Last reviewed 2025-10-27 · How we verify

NCT05299515: HEAL Together

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence

Completed NA Last updated 27 October 2025

What this trial tests

NA trial testing Peer-Delivered Behavioral Activation ("Peer Activate") in Substance-Related Disorders in 200 participants. Completed in 24 September 2025.

Timeline

5 April 2022

Primary endpoint
24 September 2025

24 September 2025

Quick facts

Lead sponsor	University of Maryland, College Park
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	200
Start date	5 April 2022
Primary completion	24 September 2025
Estimated completion	24 September 2025
Sites	2 locations across United States

Drugs / interventions tested

Peer-Delivered Behavioral Activation ("Peer Activate")

Conditions studied

Substance-Related Disorders — all drugs for Substance-Related Disorders →
Opioid Medication Assisted Treatment — all drugs for Opioid Medication Assisted Treatment →
Opioid Use Disorder — all drugs for Opioid Use Disorder →
Opioid Use — all drugs for Opioid Use →

Sponsor

University of Maryland, College Park

Who can join

18 and older, any sex, with Substance-Related Disorders or Opioid Medication Assisted Treatment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) among low-income, minority individuals living with opioid use disorder (OUD) in Baltimore, Maryland. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this Type 1 hybrid effectiveness-implementation randomized controlled trial (RCT), we will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over six months.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Peer recovery specialist-delivered, behavioral activation intervention to improve retention in methadone treatment: Results from an open-label, Type 1 hybrid effectiveness-implementation pilot trial.
Magidson JF, Kleinman MB, Bradley V, Anvari MS, et al · · 2022 · cited 21× · PMID 35932644 · DOI 10.1016/j.drugpo.2022.103813
Reduction in substance use stigma following a peer-recovery specialist behavioral activation intervention.
Kleinman MB, Anvari MS, Felton JW, Bradley VD, et al · · 2024 · cited 9× · PMID 39003894 · DOI 10.1016/j.drugpo.2024.104511
"You rise up and then you start pulling people up with you": Patient experiences with a peer-delivered behavioral activation intervention to support methadone treatment.
Kleinman MB, Hines AC, Anvari MS, Bradley VD, et al · · 2023 · cited 3× · PMID 37866292 · DOI 10.1016/j.drugpo.2023.104234
Substance use stigma mechanisms associated with greater depressive symptoms, substance use-related problems, and lower behavioral activation.
Anvari MS, Sacko CA, Triplett NS, Bradley VD, et al · · 2026 · PMID 42256591 · DOI 10.1016/j.abrep.2026.100705
"HEAL together": a randomized, hybrid type 1 effectiveness-implementation trial protocol of a peer-delivered behavioral activation intervention to improve methadone treatment retention.
Magidson JF, Bradley VD, Anane JS, Kleinman MB, et al · · 2025 · PMID 40756389 · DOI 10.3389/fpubh.2025.1637846

Verify or expand the search:

Other trials of Peer-Delivered Behavioral Activation ("Peer Activate")

Trials testing the same drug.

NCT05973838 — Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention · NA · recruiting

Other recruiting trials for Substance-Related Disorders

Currently open trials in the same condition.

NCT06676059 — SMART-r: Substance Monitoring and Active Relapse Tracking Repository · recruiting
NCT05910580 — Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years · NA · recruiting
NCT06387290 — Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits · Phase 3 · recruiting
NCT05763537 — Understanding the Role of Doulas in Supporting People With PMADs · NA · recruiting
NCT06685003 — Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families · NA · recruiting

Other University of Maryland, College Park trials

Trials by the same sponsor.

NCT07134543 — Using the Smart Underwear Device to Determine a Baseline of Flatus Activity Normalized to Fiber Intake · recruiting
NCT07162376 — How Clinical and Personal Information Shape Physicians' Risk Judgments · NA · completed
NCT06985641 — Khanya Ekhaya: A Home-Based Intervention · NA · not yet recruiting
NCT06724705 — Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumpti · NA · recruiting
NCT06305039 — Optimizing Bilateral and Single-sided-deafness Cochlear Implants for Functioning in Complex Auditory Environments · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05299515 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Maryland, College Park
Last refreshed: 27 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05299515.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing