Who is sponsoring NCT05973838?

NCT05973838 is sponsored by University of Maryland, College Park.

What drugs are being tested in NCT05973838?

Interventions in NCT05973838: Peer-Delivered Behavioral Activation ("Peer Activate").

What condition does NCT05973838 study?

NCT05973838 studies Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders.

Is NCT05973838 still recruiting?

NCT05973838 is currently recruiting now. Last updated 8 October 2025.

Last reviewed 2025-10-08 · How we verify

NCT05973838: PRISM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

Recruiting now NA Last updated 8 October 2025

What this trial tests

NA trial testing Peer-Delivered Behavioral Activation ("Peer Activate") in Polysubstance Addiction in 180 participants. Currently enrolling.

Timeline

15 June 2023

Primary endpoint
1 July 2027

1 September 2027

Quick facts

Lead sponsor	University of Maryland, College Park
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	180
Start date	15 June 2023
Primary completion	1 July 2027
Estimated completion	1 September 2027
Sites	4 locations across United States

Drugs / interventions tested

Peer-Delivered Behavioral Activation ("Peer Activate")

Conditions studied

Polysubstance Addiction — all drugs for Polysubstance Addiction →
Opioid Medication Assisted Treatment — all drugs for Opioid Medication Assisted Treatment →
Treatment Adherence — all drugs for Treatment Adherence →
Retention in Care — all drugs for Retention in Care →

Sponsor

University of Maryland, College Park

Who can join

18 and older, any sex, with Polysubstance Addiction or Opioid Medication Assisted Treatment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in underserved areas. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized controlled trial (RCT), the investigators will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over twelve months.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Reduction in substance use stigma following a peer-recovery specialist behavioral activation intervention.
Kleinman MB, Anvari MS, Felton JW, Bradley VD, et al · · 2024 · cited 9× · PMID 39003894 · DOI 10.1016/j.drugpo.2024.104511
Implementation Factors Influencing Peer-Delivered Behavioral Evidence-Based Interventions for Substance Use Disorders: A Scoping Review.
Bell JS, Tillson M, Anvari MS, Blonigen DM, et al · · 2025 · cited 1× · PMID 40839338 · DOI 10.1007/s10488-025-01470-x
"Stigma is our most powerful enemy": Understanding opioid use disorder stigma and the role of peer support in rural Maryland.
Anvari MS, Sacko CA, Atkinson GE, Triplett NS, et al · · 2025 · cited 1× · PMID 40680484 · DOI 10.1016/j.drugpo.2025.104924

Verify or expand the search:

Other trials of Peer-Delivered Behavioral Activation ("Peer Activate")

Trials testing the same drug.

NCT05299515 — Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence · NA · completed

Other University of Maryland, College Park trials

Trials by the same sponsor.

NCT07134543 — Using the Smart Underwear Device to Determine a Baseline of Flatus Activity Normalized to Fiber Intake · recruiting
NCT07162376 — How Clinical and Personal Information Shape Physicians' Risk Judgments · NA · completed
NCT06985641 — Khanya Ekhaya: A Home-Based Intervention · NA · not yet recruiting
NCT06724705 — Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumpti · NA · recruiting
NCT06305039 — Optimizing Bilateral and Single-sided-deafness Cochlear Implants for Functioning in Complex Auditory Environments · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05973838 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Maryland, College Park
Last refreshed: 8 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05973838.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing