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Opioid Anesthesia
Opioid anesthesia works by binding to opioid receptors in the central nervous system to produce analgesia and sedation for surgical procedures.
Opioid anesthesia works by binding to opioid receptors in the central nervous system to produce analgesia and sedation for surgical procedures. Used for Anesthesia induction and maintenance during surgical procedures, Perioperative analgesia.
At a glance
| Generic name | Opioid Anesthesia |
|---|---|
| Sponsor | University Hospital, Grenoble |
| Drug class | Opioid agonist |
| Target | Opioid receptors (mu, delta, kappa) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Opioids act as agonists at mu, delta, and kappa opioid receptors throughout the brain and spinal cord, reducing pain perception and producing sedation and unconsciousness. In anesthetic practice, opioids are typically combined with other agents (hypnotics, muscle relaxants) to achieve balanced anesthesia. Common opioids used in anesthesia include fentanyl, remifentanil, and sufentanil.
Approved indications
- Anesthesia induction and maintenance during surgical procedures
- Perioperative analgesia
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Chest wall rigidity
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Management of Pain in Lumbar Arthrodesis (PHASE4)
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Compared Reversed US-Guided Dorsal Penile Nerve Block (RUSDPNB) With DPNB in Circumcisions for Pediatric Patients (NA)
- Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery (NA)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |