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Preservative Free Morphine
Preservative Free Morphine is a Opioid agonist Small molecule drug developed by Icahn School of Medicine at Mount Sinai. It is currently FDA-approved for Moderate to severe acute and chronic pain, Palliative care and cancer pain. Also known as: Duramorph.
Morphine is an opioid agonist that binds to mu opioid receptors in the central and peripheral nervous system to produce analgesia and other opioid effects.
Morphine is an opioid agonist that binds to mu opioid receptors in the central and peripheral nervous system to produce analgesia and other opioid effects. Used for Moderate to severe acute and chronic pain, Palliative care and cancer pain.
At a glance
| Generic name | Preservative Free Morphine |
|---|---|
| Also known as | Duramorph |
| Sponsor | Icahn School of Medicine at Mount Sinai |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Morphine activates mu (μ) opioid receptors, which are G-protein coupled receptors found throughout the brain, spinal cord, and peripheral tissues. This activation modulates pain perception, reduces anxiety, and produces sedation. The preservative-free formulation eliminates additives that may cause adverse reactions, making it suitable for sensitive patient populations or specific routes of administration such as intrathecal or epidural delivery.
Approved indications
- Moderate to severe acute and chronic pain
- Palliative care and cancer pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Respiratory depression
- Dependence and tolerance
Key clinical trials
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine (PHASE4)
- Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection. (PHASE3)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Effect of Intrathecal Morphine on Quality of Recovery After Laparoscopic Gynecological Surgery (NA)
- Efficacy and Safety of Intrathecal Morphine for Postoperative Pain Management Following Planned Caesarean Section (PHASE4)
- Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery (PHASE4)
- Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy (NA)
- Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Preservative Free Morphine CI brief — competitive landscape report
- Preservative Free Morphine updates RSS · CI watch RSS
- Icahn School of Medicine at Mount Sinai portfolio CI
Frequently asked questions about Preservative Free Morphine
What is Preservative Free Morphine?
How does Preservative Free Morphine work?
What is Preservative Free Morphine used for?
Who makes Preservative Free Morphine?
Is Preservative Free Morphine also known as anything else?
What drug class is Preservative Free Morphine in?
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What are the side effects of Preservative Free Morphine?
What does Preservative Free Morphine target?
Related
- Drug class: All Opioid agonist drugs
- Target: All drugs targeting Mu (μ) opioid receptor
- Manufacturer: Icahn School of Medicine at Mount Sinai — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Moderate to severe acute and chronic pain
- Indication: Drugs for Palliative care and cancer pain
- Also known as: Duramorph
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing