Last reviewed · How we verify
Remifentanil 2 µg/kg
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation.
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Intraoperative analgesia during general anesthesia, Sedation and analgesia in mechanically ventilated patients in intensive care settings.
At a glance
| Generic name | Remifentanil 2 µg/kg |
|---|---|
| Sponsor | Rigshospitalet, Denmark |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Analgesia |
| Phase | FDA-approved |
Mechanism of action
Remifentanil activates mu opioid receptors, which inhibit pain signal transmission and modulate consciousness. It is an ester-based opioid that is rapidly metabolized by non-specific plasma and tissue esterases, resulting in a very short half-life (approximately 10–20 minutes) and rapid offset of action, making it suitable for intraoperative and short-procedure analgesia.
Approved indications
- Intraoperative analgesia during general anesthesia
- Sedation and analgesia in mechanically ventilated patients in intensive care settings
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Muscle rigidity
- Nausea and vomiting
Key clinical trials
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Propofol vs Remifentanil for Sedation in Gastroscopy (NA)
- qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery (NA)
- The Effects of Three Different Anesthetic Methods on Postoperative Agitation (NA)
- Comparison of the Effects of Total Intravenous Anaesthesia With Target-Controlled Infusion (TCI) and Inhalation Anaesthesia on Airway Complications During Extubation and in the Early Postoperative Period in Thyroidectomy Surgery (NA)
- Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2 (NA)
- Fentanyl vs. Remifentanil in Laparoscopic Cholecystectomy: Effects on Bowel Function and Pain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Remifentanil 2 µg/kg CI brief — competitive landscape report
- Remifentanil 2 µg/kg updates RSS · CI watch RSS
- Rigshospitalet, Denmark portfolio CI