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IN fentanyl
Intranasal fentanyl is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to provide rapid pain relief.
Intranasal fentanyl is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to provide rapid pain relief. Used for Acute pain management in opioid-tolerant patients, Breakthrough pain.
At a glance
| Generic name | IN fentanyl |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Opioid agonist |
| Target | Mu-opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Fentanyl is a synthetic opioid that activates mu-opioid receptors throughout the brain and spinal cord, modulating pain perception and transmission. The intranasal formulation allows for rapid mucosal absorption, enabling faster onset of analgesia compared to oral routes. This is particularly useful for acute or breakthrough pain management in opioid-tolerant patients.
Approved indications
- Acute pain management in opioid-tolerant patients
- Breakthrough pain
Common side effects
- Dizziness
- Somnolence
- Nausea
- Respiratory depression
- Headache
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (PHASE3)
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade (PHASE2)
- HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids (NA)
- Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |