Assistance Publique - Hôpitaux de Paris

Quick facts

Marketed products

• 14-day antibiotic therapy
• 2: Propofol
• AG infusion for 5 days
• AG infusion most 1 dose · Emergency medicine
  AG infusion is used to treat acute bleeding.
• Anhydrous Amiloride Hydrochloride · Cardiovascular
  Amiloride is a potassium-sparing diuretic that blocks sodium reabsorption in the collecting duct of the nephron, thereby increasing sodium and water excretion while retaining potassium.
• Antiplatelet therapy · Cardiovascular
  Antiplatelet therapy inhibits platelet aggregation to prevent blood clot formation and reduce thrombotic events.
• Aspirin and Clopidogrel · Cardiovascular
  Aspirin and clopidogrel together inhibit platelet aggregation through different pathways to prevent blood clots.
• Aspirin and clopidogrel / Prasugrel · Cardiovascular
  Aspirin and clopidogrel/prasugrel are antiplatelet agents that inhibit platelet aggregation through different pathways to prevent thrombotic events.
• Baricitinib Oral Tablet [Olumiant]
• becaplermin gel
• bee venom · Immunology, Rheumatology
  Bee venom contains multiple bioactive peptides and enzymes that modulate immune function and reduce inflammation through activation of anti-inflammatory pathways and immune cell regulation.
• Beta-blockers withdrawal
• Bevacizumab Injection
• Biological samples
• Botulinum Toxin A (Botox ) · Neurology; Dermatology; Aesthetics
  Botulinum toxin A blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
• Brentuximab Vedotin (Bv) · Oncology
  Brentuximab vedotin is an antibody-drug conjugate that binds to CD30 on tumor cells and delivers a microtubule-disrupting toxin to induce cell death.
• Cholecalciferol 12 000 UI · Nutritional deficiency / Bone health
  Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
• Continuation of OMA treatment
• continuation of oxytocin administration · Obstetrics / Gynecology
  Oxytocin is a peptide hormone that binds to oxytocin receptors to stimulate uterine contractions and promote milk letdown during labor and postpartum hemorrhage management.
• continuous pivotal βL-AB · Infectious Diseases
  βL-AB is a beta-lactamase inhibitor that works by inhibiting the bacterial enzyme beta-lactamase, which breaks down beta-lactam antibiotics.
• Conventional strategy Aspirin · Cardiovascular; Pain management; Inflammation
  Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing the production of thromboxane A2 and other prostaglandins to decrease platelet aggregation and inflammation.
• Conversion at day 7 ± 3 Prograf® to Advagraf®
• Course of amoxicillin
• Cyclophosphamide, Azathioprine,prednisone,methylprednisolone · Immunology
  This combination regimen suppresses the immune system through multiple pathways: cyclophosphamide and azathioprine inhibit lymphocyte proliferation, while corticosteroids (prednisone and methylprednisolone) broadly suppress inflammatory and immune responses.
• Decrease Tocilizumab, Abatacept
• Deescalation therapy · Oncology, Infectious Diseases, Critical Care
  De-escalation therapy is a treatment strategy that reduces the intensity, duration, or number of therapeutic agents used after initial disease control is achieved.
• discontinuation of oxytocin administration · Obstetrics
  Discontinuation of oxytocin administration removes the exogenous hormone that stimulates uterine contractions and milk letdown.
• DMARD maintenance
• during one week for the active treatments
• Evaluation of vaccines against flu · Immunology
  Flu vaccines stimulate the immune system to produce antibodies and cellular immunity against influenza virus strains, providing protection against infection and severe disease.
• Hydrea® (hydroxyurea ) · Oncology; Hematology
  Hydroxyurea inhibits ribonucleotide reductase, reducing deoxyribonucleotide synthesis and slowing DNA replication in rapidly dividing cells.
• influenza vaccination · Immunology
  Influenza vaccination stimulates the immune system to produce antibodies and cellular immunity against circulating influenza virus strains.
• Interleukin 2 · Oncology
  Interleukin-2 (IL-2) is a cytokine that activates and proliferates T cells and natural killer cells to enhance immune response against cancer and infections.
• intermittent pivotal βL-AB · Infectious disease
  Intermittent pivotal βL-AB works by inhibiting the beta-lactamase enzyme.
• irbesartan, amlodipine and hydrochlorothiazide · Cardiovascular
  This triple-combination antihypertensive reduces blood pressure through three complementary mechanisms: blocking angiotensin II receptors, inhibiting calcium influx into vascular smooth muscle, and promoting sodium and water excretion.
• IV Antibacterial Agents · Infectious Disease
  IV antibacterial agents kill or inhibit the growth of bacteria through various mechanisms including cell wall disruption, protein synthesis inhibition, or DNA damage.
• Ivacaftor+lumacaftor · Respiratory / Genetic disease
  Lumacaftor corrects the trafficking of defective CFTR protein to the cell surface, while ivacaftor enhances the channel activity of CFTR, together restoring chloride transport in cystic fibrosis.
• Ketamine-Morphine · Anesthesia, Pain Management
  Ketamine-Morphine is a fixed-dose combination that combines NMDA receptor antagonism (ketamine) with mu-opioid receptor agonism (morphine) to provide analgesia and anesthesia.
• Lenvatinib Pill
• Maintaining carbapenem therapy · Infectious Disease
  Carbapenem antibiotics inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins and disrupting peptidoglycan cross-linking.

Phase 3 pipeline

• acid mycophenolic (Myfortic) · Immunology
  Acid mycophenolic inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine nucleotides.
• Administration of AVP · Critical Care / Intensive Care Medicine
  AVP is an arginine vasopressin analog that acts as a vasopressor agent to increase blood pressure and peripheral vascular resistance.
• Administration of placebo hydrocortisone
  Placebo hydrocortisone has no active pharmacological effect, serving as an inert control in clinical trials.
• β-adrenergic blocker propranolol · Cardiovascular
  Propranolol blocks the action of beta-adrenergic receptors in the body, reducing the effects of the sympathetic nervous system.
• Aracytine (Ara C) · Oncology
  Cytarabine is a nucleoside analog that inhibits DNA synthesis by being incorporated into DNA, leading to chain termination and cell death.
• Aspegic ® (Aspirin) · Cardiovascular; Pain management; Inflammation
  Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing the production of prostaglandins and thromboxane to decrease inflammation, pain, and platelet aggregation.
• Aspirin + Acid folic · Cardiovascular
  Aspirin inhibits platelet aggregation via COX inhibition while folic acid supports cellular methylation and DNA synthesis.
• BEVA+SOC · Oncology
  BEVA+SOC combines bevacizumab (an anti-VEGF monoclonal antibody) with standard of care chemotherapy to inhibit tumor angiogenesis and improve chemotherapy efficacy.
• bezafibrate (drug) · Cardiovascular
  Bezafibrate is a fibric acid derivative that activates peroxisome proliferator-activated receptor alpha (PPAR-alpha), leading to increased lipolysis and decreased lipogenesis.
• Bortezomib +Dexamethasone regimen · Oncology
  Bortezomib inhibits the proteasome to trigger cancer cell death, while dexamethasone is a corticosteroid that enhances anti-myeloma effects and reduces inflammation.
• BOTOX®, Allergan · Neurology, Dermatology, Ophthalmology
  BOTOX blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary paralysis of muscles.
• Botulinum Toxin Type A Injection [Xeomin] · Neurology; Aesthetics
  Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
• BPG
  BPG is a recombinant human blood product or biopharmaceutical candidate in development by Assistance Publique - Hôpitaux de Paris.
• Calcineurin inhibitors maintenance · Immunology
  Calcineurin inhibitors suppress T-cell activation by blocking calcineurin phosphatase, preventing IL-2 production and T-cell proliferation.
• Clonazepam/Placebo levetiracetam IV · Neurology
  Clonazepam enhances GABAergic inhibition in the central nervous system to reduce seizure activity, while levetiracetam modulates neuronal excitability through an unknown mechanism, and this trial compares clonazepam/placebo with IV levetiracetam.
• Combination of antibiotics · Infectious Disease
  A combination of antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein production, targeting multiple pathways to overcome resistance.
• Continue the antimicrobial treatment · Infectious Disease
  This is a treatment directive to continue an existing antimicrobial regimen rather than a specific drug entity.
• continuous ropivacaine preperitoneal infusion · Pain management / Anesthesia
  Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission when infused continuously into the preperitoneal space during and after abdominal surgery.
• Cortancyl Oral Tablet · Immunology / Rheumatology / General Anti-inflammatory
  Cortancyl is a corticosteroid that suppresses immune and inflammatory responses by binding to glucocorticoid receptors.
• corticosteroid and azathioprine · Immunology
  Corticosteroids suppress the immune system by inhibiting the production of inflammatory cytokines, while azathioprine is an immunosuppressive medication that interferes with DNA synthesis.
• Corticosteroid (prednisolone) · Immunology
  Prednisolone suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Corticosteroids alone · Immunology
  Corticosteroids suppress immune and inflammatory responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Corticosteroids + Rivaroxaban · Immunology / Cardiovascular
  This combination uses corticosteroids to suppress inflammation and immune responses while rivaroxaban prevents blood clots by inhibiting Factor Xa in the coagulation cascade.
• corticotherapy · Other
• Cyclic peptide Fertiline · Reproductive Health / Fertility
  Fertiline is a cyclic peptide that modulates reproductive hormone signaling to enhance fertility.
• Cyclophosphamide and azathioprine · Immunology / Rheumatology
  This combination uses cyclophosphamide as an alkylating agent and azathioprine as a purine antagonist to suppress immune cell proliferation and function.
• cyclophosphamide/azathioprine · Oncology/Immunology
  Cyclophosphamide is an alkylating agent that interferes with DNA replication, while azathioprine is a purine synthesis inhibitor that suppresses the immune system.
• Cyclophosphamide + Bortezomib + Dexamethasone regimen · Oncology
  This three-drug combination kills cancer cells through DNA damage (cyclophosphamide), proteasome inhibition (bortezomib), and glucocorticoid immunosuppression (dexamethasone).
• Cyclosporine (CsA) · Immunology
  Cyclosporine inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing IL-2 transcription.
• Dalbavancin administration · Infectious Disease
  Dalbavancin is a lipoglycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala peptidoglycan precursors.
• Dapsone (Disulone®) · Dermatology, Infectious Disease, Immunology
  Dapsone is a sulfone antibiotic that inhibits bacterial dihydrofolate reductase and has immunomodulatory properties including suppression of neutrophil function and complement activation.
• DAPT strategy · Cardiovascular
  DAPT (Dual Antiplatelet Therapy) strategy involves the concurrent use of two antiplatelet agents to prevent thrombotic events in cardiovascular disease.
• Dexamfetamine sulphate · Neurology; Psychiatry
  Dexamfetamine sulphate is a central nervous system stimulant that increases the release and blocks the reuptake of dopamine and norepinephrine in the brain.
• Diuretics : Furosemide · Cardiovascular
  Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting rapid urinary excretion of water and electrolytes.
• Duoderm Hydrogel™ · Wound Care
  DuoDERM Hydrogel is a moisture-donating hydrogel wound dressing that maintains a moist wound environment to promote healing.
• EPOETINE ALPHA · Hematology
  Epoetin alfa is a recombinant erythropoietin that stimulates red blood cell production by binding to erythropoietin receptors on bone marrow progenitor cells.
• erythomycin · Other
• Ethiodized Oil-based emulsion · Oncology
  Ethiodized oil-based emulsion acts as a radiopaque contrast agent and immunomodulatory agent that enhances imaging and may stimulate immune responses against cancer cells.
• Experimental for antifungals · Infectious Disease
  This experimental antifungal drug inhibits fungal cell wall or membrane synthesis to prevent fungal growth and proliferation.
• Experimental for steroid · Immunology / Inflammation
  This experimental steroid modulates inflammatory and immune responses through glucocorticoid receptor signaling.

Phase 2 pipeline

• A collection of maternal plasma and serum
• Abiraterone acetate escalated dose · Oncology
  Abiraterone acetate is a CYP17A1 inhibitor that blocks androgen synthesis, reducing testosterone production to treat androgen-dependent cancers.
• Abiraterone acetate standard dose · Oncology
  Inhibits CYP17, an enzyme involved in the production of androgens.
• active FMT
• ALTIM, cortivazol injections · Rheumatology
  Cortivazol injections are corticosteroids that reduce inflammation and suppress the immune system.
• analyzes in singles cells
• Annexin · Other
• Azacitidine associated with Idarubicine · Oncology
  Azacitidine is a DNA methyltransferase inhibitor, and Idarubicin is an anthracycline antibiotic that intercalates DNA.
• Azacitidine associated with Lenalidomide · Oncology
  Azacitidine is a DNA methyltransferase inhibitor.
• Azacitidine associated with Valproic acid · Oncology
  Azacitidine is a hypomethylating agent that works by inhibiting DNA methyltransferases, leading to increased expression of tumor suppressor genes.
• Bio collection
• Bio-specimen collected
• Blood sample at D1, D3 and D7
• Blood sample for nutritional assessment
• Blood samples and buccal swabs
• brivaracétam
• Bronchoalveolar lavage fluid collection · Pulmonology/Respiratory
  Bronchoalveolar lavage fluid collection is a diagnostic sampling procedure that retrieves cellular and fluid samples from the lower respiratory tract for analysis.
• C-peptide proinsulin ratio

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Assistance Publique - Hôpitaux de Paris portfolio CI brief
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