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Combination of antibiotics
Combination of antibiotics is a Antibiotic combination Small molecule drug developed by Assistance Publique - Hôpitaux de Paris. It is currently in Phase 3 development for Bacterial infections (specific indication not publicly detailed for this Phase 3 combination). Also known as: Ceftriaxone; clarithromycin, metronidazole.
A combination of antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein production, targeting multiple pathways to overcome resistance.
A combination of antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein production, targeting multiple pathways to overcome resistance. Used for Bacterial infections (specific indication not publicly detailed for this Phase 3 combination).
At a glance
| Generic name | Combination of antibiotics |
|---|---|
| Also known as | Ceftriaxone; clarithromycin, metronidazole |
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Antibiotic combination |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Antibiotic combinations typically pair agents with different mechanisms—such as beta-lactams that disrupt peptidoglycan cross-linking with aminoglycosides or fluoroquinolones that inhibit DNA gyrase—to achieve broader spectrum coverage and reduce the emergence of resistant strains. This approach is particularly valuable in treating polymicrobial infections or infections caused by multidrug-resistant organisms where monotherapy may be insufficient.
Approved indications
- Bacterial infections (specific indication not publicly detailed for this Phase 3 combination)
Common side effects
- Gastrointestinal disturbance
- Allergic reaction
- Nephrotoxicity
- Ototoxicity
Key clinical trials
- Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis (NA)
- Acupuncture for Colorectal sUrgery Recovery Enhancement: A Randomized Controlled Trial Evaluating Gastrointestinal Functional Recovery After Minimally Invasive Resection (NA)
- Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections (PHASE2)
- Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (PHASE2)
- APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis) (PHASE2)
- Linezolid Plus Standard of Care (NA)
- Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity (PHASE2, PHASE3)
- Antibiotic Use & Open Fracture of the Lower Extremity (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Combination of antibiotics CI brief — competitive landscape report
- Combination of antibiotics updates RSS · CI watch RSS
- Assistance Publique - Hôpitaux de Paris portfolio CI
Frequently asked questions about Combination of antibiotics
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Related
- Drug class: All Antibiotic combination drugs
- Manufacturer: Assistance Publique - Hôpitaux de Paris — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Bacterial infections (specific indication not publicly detailed for this Phase 3 combination)
- Also known as: Ceftriaxone; clarithromycin, metronidazole