Antibiotic combination

This page covers all Antibiotic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Bacterial DNA (metronidazole); bacterial 50S ribosome (azithromycin), Bacterial cell wall (vancomycin), 30S ribosome (gentamicin), bacterial RNA polymerase (rifampin), Bacterial dihydrofolate reductase, dihydropteroate synthase, and anaerobic DNA.

Targets

Bacterial DNA (metronidazole); bacterial 50S ribosome (azithromycin) · Bacterial cell wall (vancomycin), 30S ribosome (gentamicin), bacterial RNA polymerase (rifampin) · Bacterial dihydrofolate reductase, dihydropteroate synthase, and anaerobic DNA · Bacterial DNA (metronidazole); bacterial cell wall/penicillin-binding proteins (amoxicillin) · Bacterial cell wall (vancomycin) and bacterial RNA polymerase (rifampin) · Bacterial 30S ribosome (tetracycline); anaerobic DNA/RNA (metronidazole) · Bacterial DNA (metronidazole); bacterial 30S ribosome (doxycycline) · Bacterial 50S ribosome (azithromycin); bacterial RNA polymerase (rifampin) · Bacterial ribosome (50S subunit for clindamycin; 30S subunit for gentamicin) · Bacterial 30S ribosome (doxycycline); bacterial RNA polymerase (rifampin)

Marketed (8)

• metronidazole and azithromycin · University of Alabama at Birmingham · Infectious Disease
  This combination uses metronidazole to disrupt bacterial DNA and azithromycin to inhibit bacterial protein synthesis, together targeting anaerobic and aerobic pathogens.
• Vancomycin plus Gentamicin plus Rifampin · Michael E. DeBakey VA Medical Center · Infectious Disease
  This triple-antibiotic combination kills bacteria through three complementary mechanisms: vancomycin and gentamicin inhibit protein synthesis and cell wall integrity, while rifampin inhibits bacterial RNA polymerase.
• Multi-Dose Antibiotic · The Cleveland Clinic · Infectious Disease
  A multi-dose antibiotic formulation that delivers multiple antimicrobial agents to treat bacterial infections.
• trimethoprim-sulfamethoxazole + metronidazole · Halmstad County Hospital · Infectious Disease
  This combination uses two antibiotics with different mechanisms—trimethoprim-sulfamethoxazole inhibits bacterial folate synthesis, while metronidazole disrupts DNA in anaerobic organisms—to provide broad-spectrum coverage against aerobic and anaerobic bacteria.
• Administration of Metronidazole plus Amoxicillin · University of Chile · Infectious Disease
  Metronidazole and amoxicillin together provide broad-spectrum antimicrobial coverage by inhibiting bacterial cell wall synthesis and DNA replication.
• Vancomycin plus Rifampin · Michael E. DeBakey VA Medical Center · Infectious Disease
  Vancomycin and rifampin work synergistically to inhibit bacterial cell wall and protein synthesis, providing broad-spectrum bactericidal activity against resistant gram-positive organisms.
• Tetracycline,Metronidazole · Shanghai Jiao Tong University School of Medicine · Infectious Disease
  This combination of tetracycline (a protein synthesis inhibitor) and metronidazole (a nucleic acid damaging agent) works synergistically to kill bacteria and anaerobic microorganisms through dual antimicrobial pathways.
• metronidazole and doxycycline · Hospital de Clinicas de Porto Alegre · Infectious Disease
  Metronidazole and doxycycline together provide broad-spectrum antimicrobial coverage by disrupting bacterial DNA synthesis and protein production.

Phase 3 pipeline (8)

• Azithromycin and Rifampin · University of South Florida · Infectious Disease
  Azithromycin and rifampin are a combination of two antibiotics that work synergistically to inhibit bacterial protein synthesis and RNA polymerase, respectively, to treat infections.
• CJ-12420/Clarithromycin/Amoxicillin · HK inno.N Corporation · Infectious Disease
  CJ-12420 is a novel compound combined with clarithromycin and amoxicillin to provide enhanced antimicrobial activity, likely through synergistic bacterial cell wall disruption and protein synthesis inhibition.
• Clindamycin-gentamicin irrigation · Hospital General Universitario Elche · Infectious Disease
  A combination antibiotic irrigation solution that uses clindamycin and gentamicin to kill bacteria through inhibition of protein synthesis and cell wall disruption.
• Doxycycline and Rifampin · University of South Florida · Infectious Disease
  Doxycycline and rifampin are a combination of two antibiotics that work synergistically to inhibit bacterial protein synthesis and RNA polymerase, respectively, to treat infections.
• systemic metronidazole and amoxicillin · The Forsyth Institute · Infectious Disease / Periodontal Disease
  A combination antibiotic therapy that kills anaerobic bacteria and gram-positive cocci through DNA damage and cell wall inhibition, respectively.
• Metronidazole and Rifampin · McMaster University · Infectious Disease
  Metronidazole and rifampin are a combination of an antibiotic that disrupts bacterial DNA and an antibiotic that inhibits bacterial RNA polymerase, used together to treat infections resistant to single-agent therapy.
• Combination of antibiotics · Assistance Publique - Hôpitaux de Paris · Infectious Disease
  A combination of antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein production, targeting multiple pathways to overcome resistance.
• RHB-104 · RedHill Biopharma Limited · Gastroenterology / Immunology
  RHB-104 is a combination of three antibiotics (clarithromycin, rifabutin, and clofazimine) designed to target Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease.