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systemic metronidazole and amoxicillin
A combination antibiotic therapy that kills anaerobic bacteria and gram-positive cocci through DNA damage and cell wall inhibition, respectively.
A combination antibiotic therapy that kills anaerobic bacteria and gram-positive cocci through DNA damage and cell wall inhibition, respectively. Used for Periodontal disease / aggressive periodontitis, Oral anaerobic infections.
At a glance
| Generic name | systemic metronidazole and amoxicillin |
|---|---|
| Sponsor | The Forsyth Institute |
| Drug class | Antibiotic combination |
| Target | Bacterial DNA (metronidazole); bacterial cell wall peptidoglycan (amoxicillin) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Periodontal Disease |
| Phase | Phase 3 |
Mechanism of action
Metronidazole is a nitroimidazole that generates reactive oxygen species to damage bacterial DNA and is effective against anaerobic organisms. Amoxicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding penicillin-binding proteins. Together, this combination provides broad-spectrum coverage against oral anaerobes and facultative anaerobes commonly associated with periodontal disease.
Approved indications
- Periodontal disease / aggressive periodontitis
- Oral anaerobic infections
Common side effects
- Gastrointestinal disturbance (nausea, diarrhea)
- Metallic taste
- Allergic reaction (amoxicillin)
- Headache
- Candidiasis (oral or vaginal)
Key clinical trials
- Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy (NA)
- Amoxicillin Plus Metronidazole in Periodontal Maintenance (NA)
- Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis (NA)
- Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and QoL After Surgical Extraction of Impacted Mandibular Third Molars (PHASE3)
- Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies (PHASE4)
- Systemic Amoxicillin Plus Metronidazole in Peri-implantitis Treatment (PHASE4)
- Mechanisms and Treatment Response of Aggressive Periodontitis in Children (NA)
- Amoxicillin and Metronidazole During or After the Periodontal Treatment (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- systemic metronidazole and amoxicillin CI brief — competitive landscape report
- systemic metronidazole and amoxicillin updates RSS · CI watch RSS
- The Forsyth Institute portfolio CI