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Ketamine-Morphine
Ketamine-Morphine is a fixed-dose combination that combines NMDA receptor antagonism (ketamine) with mu-opioid receptor agonism (morphine) to provide analgesia and anesthesia.
Ketamine-Morphine is a fixed-dose combination that combines NMDA receptor antagonism (ketamine) with mu-opioid receptor agonism (morphine) to provide analgesia and anesthesia. Used for Acute pain management in hospital settings, Perioperative analgesia and anesthesia.
At a glance
| Generic name | Ketamine-Morphine |
|---|---|
| Also known as | Ketamine pre and per operative, and morphine postoperative, Ketamine Hydrochloric, Pfizer Inc., US, Morphine Pfizer Inc., US |
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Opioid-NMDA antagonist combination |
| Target | NMDA receptor (ketamine); mu-opioid receptor (morphine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ketamine acts as a non-competitive antagonist at NMDA receptors, blocking glutamate-mediated pain signaling and providing dissociative anesthesia. Morphine is a mu-opioid receptor agonist that provides opioid analgesia. The combination leverages synergistic analgesic and anesthetic effects while potentially reducing the required doses of each agent.
Approved indications
- Acute pain management in hospital settings
- Perioperative analgesia and anesthesia
Common side effects
- Dissociation
- Respiratory depression
- Sedation
- Nausea
- Dizziness
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (PHASE3)
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (PHASE2, PHASE3)
- Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery (NA)
- Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery. (NA)
- Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |