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continuous ropivacaine preperitoneal infusion
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission when infused continuously into the preperitoneal space during and after abdominal surgery.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission when infused continuously into the preperitoneal space during and after abdominal surgery. Used for Postoperative pain management following abdominal surgery, Regional anesthesia via preperitoneal infusion during abdominal procedures.
At a glance
| Generic name | continuous ropivacaine preperitoneal infusion |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management / Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve cells, thereby blocking the initiation and conduction of nerve impulses. When delivered via continuous preperitoneal infusion (between the peritoneum and abdominal wall muscles), it provides regional anesthesia and postoperative analgesia to the surgical site, reducing pain and potentially decreasing opioid requirements.
Approved indications
- Postoperative pain management following abdominal surgery
- Regional anesthesia via preperitoneal infusion during abdominal procedures
Common side effects
- Local tissue irritation or inflammation at infusion site
- Systemic toxicity (if absorbed in high concentrations)
- Temporary motor or sensory dysfunction in infusion area
Key clinical trials
- Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy (NA)
- Preperitoneal Analgesia Versus Epidural Analgesia After Open Pancreaticoduodenectomy (NA)
- CLoWI Versus PCA Morphine for Pain Control After Major Abdominal Surgery (NA)
- TAP Block vs CWI for Total Abdominal Hysterectomy, a RCT (NA)
- Continuous Preperitoneal Infusion of Local Anesthetic (CPA) Versus Epidural Infusion of Local Anesthetic (EA) in Fast-Track Open Colorectal Surgery (PHASE4)
- A Comparison of Postoperative Outcomes Provided by a Continuous Preperitoneal Infusion Versus Ultrasound Guided Rectus Sheath Block for Midline Emergency Laparotomy (NA)
- Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section (PHASE4)
- Continuous Preperitoneal Infusion of Ropivacaine After Open Liver Resection: Effect on Post-operative Recovery and Morbidity. (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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