{"id":"continuous-ropivacaine-preperitoneal-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation or inflammation at infusion site"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"},{"rate":null,"effect":"Temporary motor or sensory dysfunction in infusion area"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve cells, thereby blocking the initiation and conduction of nerve impulses. When delivered via continuous preperitoneal infusion (between the peritoneum and abdominal wall muscles), it provides regional anesthesia and postoperative analgesia to the surgical site, reducing pain and potentially decreasing opioid requirements.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission when infused continuously into the preperitoneal space during and after abdominal surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:34.095Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management following abdominal surgery"},{"name":"Regional anesthesia via preperitoneal infusion during abdominal procedures"}]},"trialDetails":[{"nctId":"NCT06761989","phase":"NA","title":"Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy","status":"RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2025-01-15","conditions":"Pain Management, Pain, Postoperative","enrollment":104},{"nctId":"NCT04375826","phase":"NA","title":"Preperitoneal Analgesia Versus Epidural Analgesia After Open Pancreaticoduodenectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2020-11-13","conditions":"Pain Management, Pain, Postoperative","enrollment":146},{"nctId":"NCT04503720","phase":"NA","title":"CLoWI Versus PCA Morphine for Pain Control After Major Abdominal Surgery","status":"COMPLETED","sponsor":"JurongHealth","startDate":"2017-12-01","conditions":"Surgical Wound, Post-Op Complication, Opioid Use","enrollment":52},{"nctId":"NCT05686382","phase":"NA","title":"TAP Block vs CWI for Total Abdominal Hysterectomy, a RCT","status":"UNKNOWN","sponsor":"Campus Bio-Medico University","startDate":"2023-01-04","conditions":"Postoperative Pain","enrollment":32},{"nctId":"NCT00915265","phase":"PHASE4","title":"Continuous Preperitoneal Infusion of Local Anesthetic (CPA) Versus Epidural Infusion of Local Anesthetic (EA) in Fast-Track Open Colorectal Surgery","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2009-10","conditions":"Open Colorectal Surgery, Early Rehabilitation After Surgery","enrollment":100},{"nctId":"NCT03228797","phase":"NA","title":"A Comparison of Postoperative Outcomes Provided by a Continuous Preperitoneal Infusion Versus Ultrasound Guided Rectus Sheath Block for Midline Emergency Laparotomy","status":"COMPLETED","sponsor":"Dr Manar Mamdouh Fahmy Elsharkawi","startDate":"2015-02-11","conditions":"Abdominal Pain","enrollment":60},{"nctId":"NCT02279628","phase":"PHASE4","title":"Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section","status":"UNKNOWN","sponsor":"Central Hospital, Nancy, France","startDate":"2014-07","conditions":"Postoperative Pain","enrollment":150},{"nctId":"NCT01890408","phase":"PHASE2","title":"Continuous Preperitoneal Infusion of Ropivacaine After Open Liver Resection: Effect on Post-operative Recovery and Morbidity.","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2013-11","conditions":"Laparotomy, Hepatic Resection","enrollment":5},{"nctId":"NCT01077752","phase":"PHASE3","title":"Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-02","conditions":"Pain, Postoperative","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"continuous ropivacaine preperitoneal infusion","genericName":"continuous ropivacaine preperitoneal infusion","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission when infused continuously into the preperitoneal space during and after abdominal surgery. Used for Postoperative pain management following abdominal surgery, Regional anesthesia via preperitoneal infusion during abdominal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}