Last reviewed 2026-04-23 · How we verify

β-adrenergic blocker propranolol

Propranolol blocks the action of beta-adrenergic receptors in the body, reducing the effects of the sympathetic nervous system.

Propranolol blocks the action of beta-adrenergic receptors in the body, reducing the effects of the sympathetic nervous system. Used for Hypertension, Angina pectoris, Atrial fibrillation for stroke prevention.

At a glance

Mechanism of action

This results in decreased heart rate, blood pressure, and cardiac output. Propranolol also has a blocking effect on beta-2 receptors in the bronchial tubes, which can help to alleviate asthma symptoms.

Approved indications

• Hypertension
• Angina pectoris
• Atrial fibrillation for stroke prevention
• Essential tremor
• Migraine prophylaxis

Common side effects

• Dizziness
• Fatigue
• Nausea
• Headache
• Bronchospasm

Key clinical trials

• Propranolol With Tislelizumab Plus GC in Neoadjuvant Bladder UC (PHASE1)
• A Real World Study of β2-Adrenergic Blocker Plus PD-1 Inhibitor in Non-Small Cell Lung Cancer
• Using Reconsolidation Blockade to Treat Trauma Related Disorders After Paris Attacks: an Effectiveness Study (PHASE3)
• The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma (PHASE4)
• the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytoma (PHASE2)
• Colorectal Metastasis Prevention International Trial 2 (PHASE2)
• Reducing Total Cardiovascular Risk in an Urban Community (PHASE4)
• Coreg and HSRs-Updated Analysis

Primary sources

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