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irbesartan, amlodipine and hydrochlorothiazide
irbesartan, amlodipine and hydrochlorothiazide is a Antihypertensive combination (ARB + calcium channel blocker + thiazide diuretic) Small molecule drug developed by Assistance Publique - Hôpitaux de Paris. It is currently FDA-approved for Hypertension (essential hypertension in patients requiring combination therapy).
This triple-combination antihypertensive reduces blood pressure through three complementary mechanisms: blocking angiotensin II receptors, inhibiting calcium influx into vascular smooth muscle, and promoting sodium and water excretion.
This triple-combination antihypertensive reduces blood pressure through three complementary mechanisms: blocking angiotensin II receptors, inhibiting calcium influx into vascular smooth muscle, and promoting sodium and water excretion. Used for Hypertension (essential hypertension in patients requiring combination therapy).
At a glance
| Generic name | irbesartan, amlodipine and hydrochlorothiazide |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Antihypertensive combination (ARB + calcium channel blocker + thiazide diuretic) |
| Target | Angiotensin II type 1 receptor (AT1R), L-type calcium channels, sodium-chloride cotransporter |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Irbesartan is an angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone release. Amlodipine is a calcium channel blocker that relaxes vascular smooth muscle. Hydrochlorothiazide is a thiazide diuretic that reduces blood volume and sodium reabsorption. Together, these agents provide synergistic blood pressure reduction through distinct pathways.
Approved indications
- Hypertension (essential hypertension in patients requiring combination therapy)
Common side effects
- Dizziness
- Fatigue
- Headache
- Hyperuricemia
- Hypokalemia
- Cough
- Peripheral edema
Key clinical trials
- Standardized Antihypertensive Treatment Protocol (NA)
- ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
- Nephropathy In Type 2 Diabetes and Cardio-renal Events (PHASE4)
- Coronavirus (COVID-19) ACEi/ARB Investigation (PHASE4)
- A Clinical Study to Compare Combination of Aliskiren+ HCTZ to Irbesartan+ HCTZ or Amlodipine+ HCTZ or HCTZ Alone in Obese Hypertensive Not Responsive to HCTZ 25 mg (PHASE3)
- PHARES Study: Management of Resistant Hypertension (PHASE4)
- AMISH : Aprovel for Management of Isolated Systolic Hypertension (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- irbesartan, amlodipine and hydrochlorothiazide CI brief — competitive landscape report
- irbesartan, amlodipine and hydrochlorothiazide updates RSS · CI watch RSS
- Assistance Publique - Hôpitaux de Paris portfolio CI
Frequently asked questions about irbesartan, amlodipine and hydrochlorothiazide
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Related
- Drug class: All Antihypertensive combination (ARB + calcium channel blocker + thiazide diuretic) drugs
- Target: All drugs targeting Angiotensin II type 1 receptor (AT1R), L-type calcium channels, sodium-chloride cotransporter
- Manufacturer: Assistance Publique - Hôpitaux de Paris — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension (essential hypertension in patients requiring combination therapy)
- Compare: irbesartan, amlodipine and hydrochlorothiazide vs similar drugs
- Pricing: irbesartan, amlodipine and hydrochlorothiazide cost, discount & access