Who is sponsoring NCT00224549?

NCT00224549 is sponsored by Assistance Publique - Hôpitaux de Paris.

What condition does NCT00224549 study?

NCT00224549 studies Hypertension.

What drugs are being tested in NCT00224549?

Interventions: irbesartan, amlodipine and hydrochlorothiazide.

What is the status of NCT00224549?

NCT00224549 is currently COMPLETED.

Last reviewed 2011-02-25 · How we verify

Management of Resistant Hypertension -Pharmacokinetic Assessment of Different Antihypertensive Regimen -Comparison of Two Treatment Strategies: Increase Sodium Depletion or Combined Blockage of Renin-angiotensin System (RAS)

NCT00224549 Phase 4 COMPLETED

The purpose of this study is to assess the efficacy of two different treatment regimens for treating resistant hypertension previously uncontrolled with at least 3 antihypertensive treatments. The study hypothesis is that these two regimens (one based on increasing diuretics and the other based on increasing renin angiotensin system blockage) may not differ in terms of efficacy.

Details

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Phase	Phase 4
Status	COMPLETED
Enrolment	180
Start date	2005-04
Completion	2009-08

Conditions

Hypertension

Interventions

irbesartan, amlodipine and hydrochlorothiazide

Primary outcomes

Mean day-time systolic blood pressure (SBP) at week 12, measured with an average blood pressure measurement (ABPM) device — at week 12
Mean day-time systolic blood pressure (SBP) at week 12, measured with an average blood pressure measurement (ABPM) device

Countries

France