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receptor agonist.","indications":["General anesthesia","Sedation"],"catalyst":""},{"name":"MEOPA","genericName":"MEOPA","slug":"meopa","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"N-acetylcystein","genericName":"N-acetylcystein","slug":"n-acetylcystein","phase":"marketed","mechanism":"N-acetylcysteine (NAC) replenishes intracellular glutathione and acts as a free radical scavenger to reduce oxidative stress and cellular damage.","indications":["Chronic obstructive pulmonary disease (COPD) with chronic bronchitis","Acetaminophen (paracetamol) overdose and toxicity","Acute respiratory distress syndrome (ARDS)","Cystic fibrosis"],"catalyst":""},{"name":"Neofordex®","genericName":"Neofordex®","slug":"neofordex","phase":"phase_3","mechanism":"Neofordex is a selective glucocorticoid receptor agonist that modulates immune and inflammatory responses with reduced systemic side effects compared to conventional corticosteroids.","indications":["Acute graft-versus-host disease (aGVHD)"],"catalyst":""},{"name":"Ofloxacine","genericName":"Ofloxacine","slug":"ofloxacine","phase":"phase_3","mechanism":"Gamma-aminobutyric acid receptor subunit alpha-2, Histamine H3 receptor, Muscarinic acetylcholine receptor M1","indications":["Abdominal abscess","Acute Moraxella catarrhalis bronchitis","Acute bacterial bronchitis","Acute bacterial peritonitis","Acute bacterial sinusitis"],"catalyst":""},{"name":"Placebo-cyclophosphamide","genericName":"Placebo-cyclophosphamide","slug":"placebo-cyclophosphamide","phase":"phase_3","mechanism":"Cyclophosphamide is an alkylating agent that interferes with DNA replication, causing cell death.","indications":["Treatment of various types of cancer, including lymphomas and leukemias"],"catalyst":""},{"name":"Salicylate ointment","genericName":"Salicylate ointment","slug":"salicylate-ointment","phase":"marketed","mechanism":"Salicylate ointment works by penetrating the skin to deliver salicylic acid, which exfoliates and removes dead skin cells while reducing inflammation and promoting healing.","indications":["Psoriasis","Seborrheic dermatitis","Warts","Calluses and corns","Acne"],"catalyst":""},{"name":"Tocilizumab, Abatacept","genericName":"Tocilizumab, Abatacept","slug":"tocilizumab-abatacept","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Tranexamic Acid 500 MG","genericName":"Tranexamic Acid 500 MG","slug":"tranexamic-acid-500-mg","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"UFH (unfractionated heparin)","genericName":"UFH (unfractionated heparin)","slug":"ufh-unfractionated-heparin","phase":"phase_3","mechanism":"UFH inhibits blood coagulation by enhancing the activity of antithrombin III, which inactivates thrombin and other clotting factors.","indications":["Prevention and treatment of venous thromboembolism","Acute coronary syndrome","Atrial fibrillation for stroke prevention","Pulmonary embolism treatment"],"catalyst":""},{"name":"Usual antibiotic treatment","genericName":"Usual antibiotic treatment","slug":"usual-antibiotic-treatment","phase":"phase_3","mechanism":"This drug inhibits bacterial cell wall synthesis.","indications":["Community-acquired pneumonia","Skin and soft tissue infections"],"catalyst":""},{"name":"Usual dose adjustment of enoxaparin","genericName":"Usual dose adjustment of enoxaparin","slug":"usual-dose-adjustment-of-enoxaparin","phase":"marketed","mechanism":"Enoxaparin is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factors Xa and IIa.","indications":["Venous thromboembolism prophylaxis","Acute deep vein thrombosis treatment","Acute pulmonary embolism treatment","Acute coronary syndrome (unstable angina and non-ST-segment elevation myocardial infarction)"],"catalyst":""},{"name":"Valacyclovir (ZELITREX)","genericName":"Valacyclovir (ZELITREX)","slug":"valacyclovir-zelitrex","phase":"marketed","mechanism":"Valacyclovir is a prodrug that is converted to acyclovir, which inhibits viral DNA polymerase to prevent herpesvirus replication.","indications":["Herpes simplex virus (HSV-1 and HSV-2) infection, including genital herpes and cold sores","Varicella-zoster virus (VZV) infection, including shingles (herpes zoster) and chickenpox","Cytomegalovirus (CMV) prophylaxis in immunocompromised patients"],"catalyst":""},{"name":"Vaxigriptetra®","genericName":"Vaxigriptetra®","slug":"vaxigriptetra","phase":"phase_3","mechanism":"Vaxigriptetra is a quadrivalent inactivated influenza vaccine that stimulates immune responses against four strains of influenza virus.","indications":["Seasonal influenza prevention in adults"],"catalyst":""},{"name":"anti-inflammatory therapy","genericName":"anti-inflammatory therapy","slug":"anti-inflammatory-therapy","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"biomarker-guided strategy","genericName":"biomarker-guided strategy","slug":"biomarker-guided-strategy","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"continuous pivotal βL-AB","genericName":"continuous pivotal βL-AB","slug":"continuous-pivotal-l-ab","phase":"marketed","mechanism":"βL-AB is a beta-lactamase inhibitor that works by inhibiting the bacterial enzyme beta-lactamase, which breaks down beta-lactam antibiotics.","indications":["Treatment of infections caused by bacteria that produce beta-lactamase enzymes, such as E. coli and Klebsiella pneumoniae"],"catalyst":""},{"name":"during one week for the active treatments","genericName":"during one week for the active treatments","slug":"during-one-week-for-the-active-treatments","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"erythomycin","genericName":"erythomycin","slug":"erythomycin","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"intermittent pivotal βL-AB","genericName":"intermittent pivotal βL-AB","slug":"intermittent-pivotal-l-ab","phase":"marketed","mechanism":"Intermittent pivotal βL-AB works by inhibiting the beta-lactamase enzyme.","indications":["Treatment of bacterial infections caused by beta-lactamase-producing bacteria"],"catalyst":""},{"name":"mRNA-1273","genericName":"mRNA-1273","slug":"mrna-1273","phase":"marketed","mechanism":"mRNA-1273 is a lipid nanoparticle-formulated messenger RNA vaccine that encodes the SARS-CoV-2 spike protein, instructing cells to produce the antigen and trigger adaptive immune responses.","indications":["COVID-19 prevention in adults and pediatric populations","COVID-19 booster vaccination"],"catalyst":""},{"name":"14-day antibiotic therapy","genericName":"14-day antibiotic therapy","slug":"14-day-antibiotic-therapy","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"A collection of maternal plasma and serum","genericName":"A collection of maternal plasma and serum","slug":"a-collection-of-maternal-plasma-and-serum","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"AG infusion for 5 days","genericName":"AG infusion for 5 days","slug":"ag-infusion-for-5-days","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"AG infusion most 1 dose","genericName":"AG infusion most 1 dose","slug":"ag-infusion-most-1-dose","phase":"marketed","mechanism":"AG infusion is used to treat acute bleeding.","indications":["Acute bleeding"],"catalyst":""},{"name":"ALTIM, cortivazol injections","genericName":"ALTIM, cortivazol injections","slug":"altim-cortivazol-injections","phase":"phase_2","mechanism":"Cortivazol injections are corticosteroids that reduce inflammation and suppress the immune system.","indications":["Rheumatoid arthritis","Psoriatic arthritis"],"catalyst":""},{"name":"Abiraterone acetate escalated dose","genericName":"Abiraterone acetate escalated dose","slug":"abiraterone-acetate-escalated-dose","phase":"phase_2","mechanism":"Abiraterone acetate is a CYP17A1 inhibitor that blocks androgen synthesis, reducing testosterone production to treat androgen-dependent cancers.","indications":["Metastatic castration-resistant prostate cancer","Castration-sensitive prostate cancer (in combination with androgen deprivation therapy)"],"catalyst":""},{"name":"Abiraterone acetate standard dose","genericName":"Abiraterone acetate standard dose","slug":"abiraterone-acetate-standard-dose","phase":"phase_2","mechanism":"Inhibits CYP17, an enzyme involved in the production of androgens.","indications":["Prostate cancer"],"catalyst":""},{"name":"AcSDKP-NH2 Cr-EDTA","genericName":"AcSDKP-NH2 Cr-EDTA","slug":"acsdkp-nh2-cr-edta","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"AcSDKP-NH2 inuline","genericName":"AcSDKP-NH2 inuline","slug":"acsdkp-nh2-inuline","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Administration of 131 iodine","genericName":"Administration of 131 iodine","slug":"administration-of-131-iodine","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Administration of AVP","genericName":"Administration of AVP","slug":"administration-of-avp","phase":"phase_3","mechanism":"AVP is an arginine vasopressin analog that acts as a vasopressor agent to increase blood pressure and peripheral vascular resistance.","indications":["Hypotension in septic shock or critical illness","Variceal bleeding in portal hypertension"],"catalyst":""},{"name":"Administration of placebo hydrocortisone","genericName":"Administration of placebo hydrocortisone","slug":"administration-of-placebo-hydrocortisone","phase":"phase_3","mechanism":"Placebo hydrocortisone has no active pharmacological effect, serving as an inert control in clinical trials.","indications":["Control arm in clinical trials (specific indication depends on parent trial)"],"catalyst":""},{"name":"Allogenic NK cells infusion","genericName":"Allogenic NK cells infusion","slug":"allogenic-nk-cells-infusion","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Anhydrous Amiloride Hydrochloride","genericName":"Anhydrous Amiloride Hydrochloride","slug":"anhydrous-amiloride-hydrochloride","phase":"marketed","mechanism":"Amiloride is a potassium-sparing diuretic that blocks sodium reabsorption in the collecting duct of the nephron, thereby increasing sodium and water excretion while retaining potassium.","indications":["Edema associated with congestive heart failure","Hypertension","Hypokalemia prevention in patients on loop or thiazide diuretics"],"catalyst":""},{"name":"Annexin","genericName":"Annexin","slug":"annexin","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Antiplatelet therapy","genericName":"Antiplatelet therapy","slug":"antiplatelet-therapy","phase":"marketed","mechanism":"Antiplatelet therapy inhibits platelet aggregation to prevent blood clot formation and reduce thrombotic events.","indications":["Acute coronary syndrome","Secondary prevention of myocardial infarction","Stroke prevention","Peripheral arterial disease"],"catalyst":""},{"name":"Aracytine (Ara C)","genericName":"Aracytine (Ara C)","slug":"aracytine-ara-c","phase":"phase_3","mechanism":"Cytarabine is a nucleoside analog that inhibits DNA synthesis by being incorporated into DNA, leading to chain termination and cell death.","indications":["Acute myeloid leukemia (AML)","Acute lymphoblastic leukemia (ALL)","Chronic myeloid leukemia (CML) in blast phase","Lymphoma"],"catalyst":""},{"name":"Aspegic ® (Aspirin)","genericName":"Aspegic ® (Aspirin)","slug":"aspegic-aspirin","phase":"phase_3","mechanism":"Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing the production of prostaglandins and thromboxane to decrease inflammation, pain, and platelet aggregation.","indications":["Acute myocardial infarction prevention and secondary prevention","Ischemic stroke prevention","Transient ischemic attack (TIA) prevention","Mild to moderate pain and fever","Rheumatoid arthritis and other inflammatory conditions"],"catalyst":""},{"name":"Aspirin + Acid folic","genericName":"Aspirin + Acid folic","slug":"aspirin-acid-folic","phase":"phase_3","mechanism":"Aspirin inhibits platelet aggregation via COX inhibition while folic acid supports cellular methylation and DNA synthesis.","indications":["Cardiovascular disease prevention or secondary prevention in patients with elevated homocysteine or folate deficiency"],"catalyst":""},{"name":"Aspirin and Clopidogrel","genericName":"Aspirin and Clopidogrel","slug":"aspirin-and-clopidogrel","phase":"marketed","mechanism":"Aspirin and clopidogrel together inhibit platelet aggregation through different pathways to prevent blood clots.","indications":["Acute coronary syndrome","Secondary prevention after myocardial infarction","Prevention of stent thrombosis after percutaneous coronary intervention"],"catalyst":""},{"name":"Aspirin and clopidogrel / Prasugrel","genericName":"Aspirin and clopidogrel / Prasugrel","slug":"aspirin-and-clopidogrel-prasugrel","phase":"marketed","mechanism":"Aspirin and clopidogrel/prasugrel are antiplatelet agents that inhibit platelet aggregation through different pathways to prevent thrombotic events.","indications":["Acute coronary syndrome (ACS) with percutaneous coronary intervention (PCI)","Secondary prevention of stent thrombosis post-PCI","Stable coronary artery disease with stent placement"],"catalyst":""},{"name":"Azacitidine associated with Idarubicine","genericName":"Azacitidine associated with Idarubicine","slug":"azacitidine-associated-with-idarubicine","phase":"phase_2","mechanism":"Azacitidine is a DNA methyltransferase inhibitor, and Idarubicin is an anthracycline antibiotic that intercalates DNA.","indications":["Acute myeloid leukemia"],"catalyst":""},{"name":"Azacitidine associated with Lenalidomide","genericName":"Azacitidine associated with Lenalidomide","slug":"azacitidine-associated-with-lenalidomide","phase":"phase_2","mechanism":"Azacitidine is a DNA methyltransferase inhibitor.","indications":["Myelodysplastic syndromes","Acute myeloid leukemia"],"catalyst":""},{"name":"Azacitidine associated with Valproic acid","genericName":"Azacitidine associated with Valproic acid","slug":"azacitidine-associated-with-valproic-acid","phase":"phase_2","mechanism":"Azacitidine is a hypomethylating agent that works by inhibiting DNA methyltransferases, leading to increased expression of tumor suppressor genes.","indications":["Acute myeloid leukemia (AML)","Myelodysplastic syndromes (MDS)"],"catalyst":""},{"name":"B vaccination","genericName":"B vaccination","slug":"b-vaccination","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"BEVA+SOC","genericName":"BEVA+SOC","slug":"beva-soc","phase":"phase_3","mechanism":"BEVA+SOC combines bevacizumab (an anti-VEGF monoclonal antibody) with standard of care chemotherapy to inhibit tumor angiogenesis and improve chemotherapy efficacy.","indications":["Metastatic colorectal cancer (bevacizumab + standard chemotherapy)","Metastatic non-small cell lung cancer (bevacizumab + standard chemotherapy)"],"catalyst":""},{"name":"BOTOX®, Allergan","genericName":"BOTOX®, Allergan","slug":"botox-allergan","phase":"phase_3","mechanism":"BOTOX blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary paralysis of muscles.","indications":["Cervical dystonia","Blepharospasm","Strabismus","Chronic migraine","Hyperhidrosis"],"catalyst":""},{"name":"Baricitinib Oral Tablet [Olumiant]","genericName":"Baricitinib Oral Tablet [Olumiant]","slug":"baricitinib-oral-tablet-olumiant","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Beta-blockers withdrawal","genericName":"Beta-blockers withdrawal","slug":"beta-blockers-withdrawal","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Bevacizumab Injection","genericName":"Bevacizumab Injection","slug":"bevacizumab-injection","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Bio collection","genericName":"Bio collection","slug":"bio-collection","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Bio-specimen collected","genericName":"Bio-specimen collected","slug":"bio-specimen-collected","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Blood sample at D1, D3 and D7","genericName":"Blood sample at D1, D3 and D7","slug":"blood-sample-at-d1-d3-and-d7","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Blood sample for nutritional assessment","genericName":"Blood sample for nutritional assessment","slug":"blood-sample-for-nutritional-assessment","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Bortezomib +Dexamethasone regimen","genericName":"Bortezomib +Dexamethasone regimen","slug":"bortezomib-dexamethasone-regimen","phase":"phase_3","mechanism":"Bortezomib inhibits the proteasome to trigger cancer cell death, while dexamethasone is a corticosteroid that enhances anti-myeloma effects and reduces inflammation.","indications":["Multiple myeloma (newly diagnosed and relapsed/refractory)","Light chain myeloma"],"catalyst":""},{"name":"Botulinum Toxin A (Botox )","genericName":"Botulinum Toxin A (Botox )","slug":"botulinum-toxin-a-botox","phase":"marketed","mechanism":"Botulinum toxin A blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","indications":["Cervical dystonia (spasmodic torticollis)","Blepharospasm","Strabismus","Hemifacial spasm","Primary axillary hyperhidrosis"],"catalyst":""},{"name":"Botulinum Toxin Type A Injection [Xeomin]","genericName":"Botulinum Toxin Type A Injection [Xeomin]","slug":"botulinum-toxin-type-a-injection-xeomin","phase":"phase_3","mechanism":"Botulinum toxin type A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","indications":["Cervical dystonia","Blepharospasm","Hemifacial spasm","Glabellar lines (aesthetic indication)","Chronic migraine"],"catalyst":""},{"name":"Bronchoalveolar lavage fluid collection","genericName":"Bronchoalveolar lavage fluid collection","slug":"bronchoalveolar-lavage-fluid-collection","phase":"phase_2","mechanism":"Bronchoalveolar lavage fluid collection is a diagnostic sampling procedure that retrieves cellular and fluid samples from the lower respiratory tract for analysis.","indications":["Diagnosis of pulmonary infections (bacterial, fungal, viral)","Evaluation of interstitial lung disease","Investigation of unexplained pulmonary infiltrates","Assessment of immunocompromised patients with respiratory symptoms"],"catalyst":""},{"name":"C-peptide proinsulin ratio","genericName":"C-peptide proinsulin ratio","slug":"c-peptide-proinsulin-ratio","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Calcineurin inhibitors maintenance","genericName":"Calcineurin inhibitors maintenance","slug":"calcineurin-inhibitors-maintenance","phase":"phase_3","mechanism":"Calcineurin inhibitors suppress T-cell activation by blocking calcineurin phosphatase, preventing IL-2 production and T-cell proliferation.","indications":["Maintenance immunosuppression in solid organ transplant recipients (kidney, heart, liver, pancreas)","Prevention of graft rejection and graft-versus-host disease"],"catalyst":""},{"name":"Cell line and virus","genericName":"Cell line and virus","slug":"cell-line-and-virus","phase":"phase_2","mechanism":"This is a cell line and virus preparation used as a research or therapeutic tool, not a traditional pharmaceutical drug with a defined molecular mechanism.","indications":[],"catalyst":""},{"name":"Cholecalciferol 12 000 UI","genericName":"Cholecalciferol 12 000 UI","slug":"cholecalciferol-12-000-ui","phase":"marketed","mechanism":"Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.","indications":["Vitamin D deficiency","Hypocalcemia","Osteomalacia","Rickets"],"catalyst":""},{"name":"Clonazepam/Placebo levetiracetam IV","genericName":"Clonazepam/Placebo levetiracetam IV","slug":"clonazepam-placebo-levetiracetam-iv","phase":"phase_3","mechanism":"Clonazepam enhances GABAergic inhibition in the central nervous system to reduce seizure activity, while levetiracetam modulates neuronal excitability through an unknown mechanism, and this trial compares clonazepam/placebo with IV levetiracetam.","indications":["Acute seizure management or status epilepticus (inferred from IV formulation and trial design)"],"catalyst":""},{"name":"Coagulation assay","genericName":"Coagulation assay","slug":"coagulation-assay","phase":"phase_2","mechanism":"A coagulation assay is a diagnostic test that measures blood clotting function and identifies coagulation disorders.","indications":["Diagnosis and monitoring of coagulation disorders","Assessment of bleeding risk prior to surgery","Monitoring of anticoagulant therapy"],"catalyst":""},{"name":"Combination of antibiotics","genericName":"Combination of antibiotics","slug":"combination-of-antibiotics","phase":"phase_3","mechanism":"A combination of antibiotics that work synergistically to inhibit bacterial cell wall synthesis and protein production, targeting multiple pathways to overcome resistance.","indications":["Bacterial infections (specific indication not publicly detailed for this Phase 3 combination)"],"catalyst":""},{"name":"Conditioning regimen","genericName":"Conditioning regimen","slug":"conditioning-regimen","phase":"phase_2","mechanism":"This conditioning regimen involves a combination of chemotherapy and radiation therapy to prepare the body for a bone marrow transplant.","indications":["Preparation for bone marrow transplant in patients with hematological malignancies"],"catalyst":""},{"name":"Continuation of OMA treatment","genericName":"Continuation of OMA treatment","slug":"continuation-of-oma-treatment","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Continue the antimicrobial treatment","genericName":"Continue the antimicrobial treatment","slug":"continue-the-antimicrobial-treatment","phase":"phase_3","mechanism":"This is a treatment directive to continue an existing antimicrobial regimen rather than a specific drug entity.","indications":["Continuation of antimicrobial treatment for unspecified infection"],"catalyst":""},{"name":"Conventional strategy Aspirin","genericName":"Conventional strategy Aspirin","slug":"conventional-strategy-aspirin","phase":"marketed","mechanism":"Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing the production of thromboxane A2 and other prostaglandins to decrease platelet aggregation and inflammation.","indications":["Acute myocardial infarction prevention and secondary prevention","Ischemic stroke prevention","Transient ischemic attack (TIA) prevention","Unstable angina","Mild to moderate pain and fever"],"catalyst":""},{"name":"Conversion at day 7 ± 3 Prograf® to Advagraf®","genericName":"Conversion at day 7 ± 3 Prograf® to Advagraf®","slug":"conversion-at-day-7-3-prograf-to-advagraf","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Cortancyl Oral Tablet","genericName":"Cortancyl Oral Tablet","slug":"cortancyl-oral-tablet","phase":"phase_3","mechanism":"Cortancyl is a corticosteroid that suppresses immune and inflammatory responses by binding to glucocorticoid receptors.","indications":["Inflammatory and autoimmune disorders (e.g., rheumatoid arthritis, lupus, vasculitis)","Allergic reactions and asthma exacerbations","Hematologic malignancies and lymphomas (as adjunctive therapy)"],"catalyst":""},{"name":"Corticosteroid (prednisolone)","genericName":"Corticosteroid (prednisolone)","slug":"corticosteroid-prednisolone","phase":"phase_3","mechanism":"Prednisolone suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Inflammatory and autoimmune disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus)","Allergic reactions and asthma","Adrenal insufficiency","Certain hematologic malignancies and lymphomas"],"catalyst":""},{"name":"Corticosteroids + Rivaroxaban","genericName":"Corticosteroids + Rivaroxaban","slug":"corticosteroids-rivaroxaban","phase":"phase_3","mechanism":"This combination uses corticosteroids to suppress inflammation and immune responses while rivaroxaban prevents blood clots by inhibiting Factor Xa in the coagulation cascade.","indications":["Phase 3 investigational combination therapy (specific indication not publicly disclosed)"],"catalyst":""},{"name":"Course of amoxicillin","genericName":"Course of amoxicillin","slug":"course-of-amoxicillin","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Cyclic peptide Fertiline","genericName":"Cyclic peptide Fertiline","slug":"cyclic-peptide-fertiline","phase":"phase_3","mechanism":"Fertiline is a cyclic peptide that modulates reproductive hormone signaling to enhance fertility.","indications":["Infertility (ovulatory dysfunction or male factor infertility)"],"catalyst":""},{"name":"Cyclophosphamide and azathioprine","genericName":"Cyclophosphamide and azathioprine","slug":"cyclophosphamide-and-azathioprine","phase":"phase_3","mechanism":"This combination uses cyclophosphamide as an alkylating agent and azathioprine as a purine antagonist to suppress immune cell proliferation and function.","indications":["Autoimmune diseases (likely vasculitis, lupus nephritis, or other systemic autoimmune conditions based on typical Phase 3 use)"],"catalyst":""},{"name":"Cyclophosphamide, Azathioprine,prednisone,methylprednisolone","genericName":"Cyclophosphamide, Azathioprine,prednisone,methylprednisolone","slug":"cyclophosphamide-azathioprine-prednisone-methylprednisolone","phase":"marketed","mechanism":"This combination regimen suppresses the immune system through multiple pathways: cyclophosphamide and azathioprine inhibit lymphocyte proliferation, while corticosteroids (prednisone and methylprednisolone) broadly suppress inflammatory and immune responses.","indications":["Severe systemic lupus erythematosus (SLE)","Severe vasculitis","Severe autoimmune conditions refractory to conventional therapy"],"catalyst":""},{"name":"Cyclosporine (CsA)","genericName":"Cyclosporine (CsA)","slug":"cyclosporine-csa","phase":"phase_3","mechanism":"Cyclosporine inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing IL-2 transcription.","indications":["Organ transplant rejection prevention (renal, cardiac, hepatic)","Autoimmune diseases (rheumatoid arthritis, psoriasis, nephrotic syndrome)"],"catalyst":""},{"name":"DAPT strategy","genericName":"DAPT strategy","slug":"dapt-strategy","phase":"phase_3","mechanism":"DAPT (Dual Antiplatelet Therapy) strategy involves the concurrent use of two antiplatelet agents to prevent thrombotic events in cardiovascular disease.","indications":["Acute coronary syndrome (ACS) with percutaneous coronary intervention (PCI)","Secondary prevention of thrombotic events post-PCI with stent placement","Stable coronary artery disease management"],"catalyst":""},{"name":"DMARD maintenance","genericName":"DMARD maintenance","slug":"dmard-maintenance","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Ddimer testing","genericName":"Ddimer testing","slug":"ddimer-testing","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Decrease Tocilizumab, Abatacept","genericName":"Decrease Tocilizumab, Abatacept","slug":"decrease-tocilizumab-abatacept","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Deep nasopharyngeal swab","genericName":"Deep nasopharyngeal swab","slug":"deep-nasopharyngeal-swab","phase":"phase_2","mechanism":"A deep nasopharyngeal swab is a diagnostic sampling procedure that collects respiratory secretions from the nasopharynx for laboratory analysis.","indications":["Detection of respiratory pathogens (e.g., SARS-CoV-2, influenza, other viruses)"],"catalyst":""},{"name":"Dexamfetamine sulphate","genericName":"Dexamfetamine sulphate","slug":"dexamfetamine-sulphate","phase":"phase_3","mechanism":"Dexamfetamine sulphate is a central nervous system stimulant that increases the release and blocks the reuptake of dopamine and norepinephrine in the brain.","indications":["Attention-deficit/hyperactivity disorder (ADHD)","Narcolepsy"],"catalyst":""},{"name":"Diuretics : Furosemide","genericName":"Diuretics : Furosemide","slug":"diuretics-furosemide","phase":"phase_3","mechanism":"Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting rapid urinary excretion of water and electrolytes.","indications":["Edema associated with congestive heart failure","Edema associated with hepatic cirrhosis","Edema associated with renal disease","Hypertension","Pulmonary edema"],"catalyst":""},{"name":"Donors","genericName":"Donors","slug":"donors","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Dose D1 of interleukin-2","genericName":"Dose D1 of interleukin-2","slug":"dose-d1-of-interleukin-2","phase":"phase_2","mechanism":"Interleukin-2 stimulates T-cell proliferation and activation.","indications":["Melanoma","Renal cell carcinoma"],"catalyst":""},{"name":"Dose D2 of Interleukin-2","genericName":"Dose D2 of Interleukin-2","slug":"dose-d2-of-interleukin-2","phase":"phase_2","mechanism":"Interleukin-2 activates and expands T cells and natural killer cells to enhance anti-tumor immune responses.","indications":["Advanced or metastatic cancer (specific indication under investigation in Phase 2)"],"catalyst":""},{"name":"Dose D3 of interleukin-2","genericName":"Dose D3 of interleukin-2","slug":"dose-d3-of-interleukin-2","phase":"phase_2","mechanism":"Interleukin-2 stimulates T-cell proliferation and activation.","indications":["Melanoma","Renal cell carcinoma"],"catalyst":""},{"name":"Duoderm Hydrogel™","genericName":"Duoderm Hydrogel™","slug":"duoderm-hydrogel","phase":"phase_3","mechanism":"DuoDERM Hydrogel is a moisture-donating hydrogel wound dressing that maintains a moist wound environment to promote healing.","indications":["Partial and full-thickness wounds","Pressure ulcers","Diabetic ulcers","Burn wounds","Surgical wounds"],"catalyst":""},{"name":"EPOETINE ALPHA","genericName":"EPOETINE ALPHA","slug":"epoetine-alpha","phase":"phase_3","mechanism":"Epoetin alfa is a recombinant erythropoietin that stimulates red blood cell production by binding to erythropoietin receptors on bone marrow progenitor cells.","indications":["Anemia associated with chronic kidney disease","Anemia in patients with cancer receiving chemotherapy","Anemia in patients with HIV infection","Perioperative anemia management"],"catalyst":""},{"name":"Epicutaneous Immunotherapy","genericName":"Epicutaneous Immunotherapy","slug":"epicutaneous-immunotherapy","phase":"phase_2","mechanism":"Allergen exposure to induce immune tolerance","indications":["Allergic rhinitis","Atopic dermatitis"],"catalyst":""},{"name":"Ethiodized Oil-based emulsion","genericName":"Ethiodized Oil-based emulsion","slug":"ethiodized-oil-based-emulsion","phase":"phase_3","mechanism":"Ethiodized oil-based emulsion acts as a radiopaque contrast agent and immunomodulatory agent that enhances imaging and may stimulate immune responses against cancer cells.","indications":["Hepatocellular carcinoma (transarterial chemoembolization or immunotherapy)"],"catalyst":""},{"name":"Experimental for antifungals","genericName":"Experimental for antifungals","slug":"experimental-for-antifungals","phase":"phase_3","mechanism":"This experimental antifungal drug inhibits fungal cell wall or membrane synthesis to prevent fungal growth and proliferation.","indications":["Invasive fungal infections (specific indication under Phase 3 evaluation)"],"catalyst":""},{"name":"Experimental for steroids and antifungals","genericName":"Experimental for steroids and antifungals","slug":"experimental-for-steroids-and-antifungals","phase":"phase_3","mechanism":"This experimental agent combines steroid and antifungal properties to modulate immune response while providing antifungal activity.","indications":["Fungal infections in immunocompromised patients (investigational)"],"catalyst":""},{"name":"Fluoro-L-thymidine-(18F)","genericName":"Fluoro-L-thymidine-(18F)","slug":"fluoro-l-thymidine-18f","phase":"phase_3","mechanism":"Fluoro-L-thymidine-(18F) is a fluorine-18 labeled nucleoside analog that accumulates in rapidly dividing cells, enabling PET imaging of cellular proliferation.","indications":["PET imaging of tumor proliferation in various cancers","Assessment of treatment response in oncology"],"catalyst":""},{"name":"Full dose CBD","genericName":"Full dose CBD","slug":"full-dose-cbd","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"HLA typing","genericName":"HLA typing","slug":"hla-typing","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Hepatocellular carcinoma","genericName":"Hepatocellular carcinoma","slug":"hepatocellular-carcinoma","phase":"phase_1","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Hydrea® (hydroxyurea )","genericName":"Hydrea® (hydroxyurea )","slug":"hydrea-hydroxyurea","phase":"marketed","mechanism":"Hydroxyurea inhibits ribonucleotide reductase, reducing deoxyribonucleotide synthesis and slowing DNA replication in rapidly dividing cells.","indications":["Chronic myeloid leukemia (CML)","Polycythemia vera","Essential thrombocythemia","Sickle cell disease (to reduce vaso-occlusive crises)"],"catalyst":""},{"name":"IMN","genericName":"IMN","slug":"imn","phase":"phase_3","mechanism":"IMN is an immunomodulatory agent designed to enhance immune responses against cancer cells.","indications":["Cancer immunotherapy (specific indication under investigation in phase 3)"],"catalyst":""},{"name":"IV Antibacterial Agents","genericName":"IV Antibacterial Agents","slug":"iv-antibacterial-agents","phase":"marketed","mechanism":"IV antibacterial agents kill or inhibit the growth of bacteria through various mechanisms including cell wall disruption, protein synthesis inhibition, or DNA damage.","indications":["Bacterial infections requiring intravenous administration (broad spectrum)"],"catalyst":""},{"name":"IV Busulfan","genericName":"IV Busulfan","slug":"iv-busulfan","phase":"phase_2","mechanism":"Alkylating agent that interferes with DNA replication","indications":["Chronic myeloid leukemia"],"catalyst":""},{"name":"IV Thiotepa","genericName":"IV Thiotepa","slug":"iv-thiotepa","phase":"phase_2","mechanism":"Thiotepa is an alkylating agent that cross-links DNA, disrupting its structure and function, leading to cell death.","indications":["Treatment of malignant pleural effusions","Treatment of ovarian cancer","Treatment of bladder cancer"],"catalyst":""},{"name":"Interferon Gamma 1-b","genericName":"Interferon Gamma 1-b","slug":"interferon-gamma-1-b","phase":"phase_3","mechanism":"Interferon Gamma 1-b is a recombinant cytokine that activates macrophages and enhances immune cell function to boost the body's antimicrobial and antitumor responses.","indications":["Chronic granulomatous disease","Severe malignant osteopetrosis","Atypical mycobacterial infections in immunocompromised patients"],"catalyst":""},{"name":"Intravenous administration of Methylprednisolone","genericName":"Intravenous administration of Methylprednisolone","slug":"intravenous-administration-of-methylprednisolone","phase":"phase_3","mechanism":"Methylprednisolone is a corticosteroid that suppresses the immune system and reduces inflammation by inhibiting inflammatory mediators and immune cell activation.","indications":["Acute inflammatory and autoimmune conditions requiring rapid immunosuppression","Multiple sclerosis relapse","Severe allergic reactions","Organ transplant rejection prophylaxis"],"catalyst":""},{"name":"Intravitreal triamcinolone injections","genericName":"Intravitreal triamcinolone injections","slug":"intravitreal-triamcinolone-injections","phase":"phase_3","mechanism":"Triamcinolone is a corticosteroid that suppresses intraocular inflammation by inhibiting inflammatory mediators and immune cell activation in the vitreous.","indications":["Diabetic macular edema","Retinal vein occlusion with macular edema","Uveitic macular edema","Age-related macular degeneration with choroidal neovascularization"],"catalyst":""},{"name":"Investigational products administration","genericName":"Investigational products administration","slug":"investigational-products-administration","phase":"phase_3","mechanism":"This drug is an investigational product that targets the PD-1/PD-L1 pathway.","indications":["Metastatic non-small cell lung cancer, PD-L1 positive","Metastatic melanoma"],"catalyst":""},{"name":"Iontophoresis with acetylcholine delivery","genericName":"Iontophoresis with acetylcholine delivery","slug":"iontophoresis-with-acetylcholine-delivery","phase":"phase_2","mechanism":"Acetylcholine delivery via iontophoresis stimulates nicotinic acetylcholine receptors.","indications":["Tourette syndrome","Dystonia"],"catalyst":""},{"name":"Ivacaftor+lumacaftor","genericName":"Ivacaftor+lumacaftor","slug":"ivacaftor-lumacaftor","phase":"marketed","mechanism":"Lumacaftor corrects the trafficking of defective CFTR protein to the cell surface, while ivacaftor enhances the channel activity of CFTR, together restoring chloride transport in cystic fibrosis.","indications":["Cystic fibrosis in patients homozygous for the F508del-CFTR mutation or heterozygous for F508del and a minimal function mutation"],"catalyst":""},{"name":"Ivermectin 400 µg/kg","genericName":"Ivermectin 400 µg/kg","slug":"ivermectin-400-g-kg","phase":"phase_3","mechanism":"Ivermectin binds to glutamate-gated chloride channels in parasites and some insects, causing paralysis and death of the organism.","indications":["Parasitic infections including onchocerciasis (river blindness)","Lymphatic filariasis","Strongyloidiasis","Scabies","Lice infestations"],"catalyst":""},{"name":"Joint puncture","genericName":"Joint puncture","slug":"joint-puncture","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Ketamine-Morphine","genericName":"Ketamine-Morphine","slug":"ketamine-morphine","phase":"marketed","mechanism":"Ketamine-Morphine is a fixed-dose combination that combines NMDA receptor antagonism (ketamine) with mu-opioid receptor agonism (morphine) to provide analgesia and anesthesia.","indications":["Acute pain management in hospital settings","Perioperative analgesia and anesthesia"],"catalyst":""},{"name":"Lenvatinib Pill","genericName":"Lenvatinib Pill","slug":"lenvatinib-pill","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Levetiracetam/Clonazepam","genericName":"Levetiracetam/Clonazepam","slug":"levetiracetam-clonazepam","phase":"phase_3","mechanism":"This combination drug pairs levetiracetam, which modulates synaptic vesicle proteins to reduce neuronal excitability, with clonazepam, a benzodiazepine that enhances GABAergic inhibition in the central nervous system.","indications":["Seizure disorders / Epilepsy (combination therapy)","Status epilepticus (acute seizure management)"],"catalyst":""},{"name":"Liberal Red blood cell transfusion","genericName":"Liberal Red blood cell transfusion","slug":"liberal-red-blood-cell-transfusion","phase":"phase_3","mechanism":"Liberal red blood cell transfusion increases circulating hemoglobin and oxygen-carrying capacity by administering donor red blood cells to patients with anemia or blood loss.","indications":["Anemia in critically ill patients","Perioperative blood loss management"],"catalyst":""},{"name":"Lovenox® (enoxaparin)","genericName":"Lovenox® (enoxaparin)","slug":"lovenox-enoxaparin","phase":"phase_3","mechanism":"Enoxaparin is a low-molecular-weight heparin that inhibits blood clotting by enhancing the activity of antithrombin III against factors Xa and IIa.","indications":["Prophylaxis of deep vein thrombosis (DVT) in patients undergoing hip or knee replacement surgery","Prophylaxis of DVT in patients with acute illness","Treatment of acute DVT and pulmonary embolism","Acute coronary syndrome (unstable angina and non-ST-segment elevation myocardial infarction)"],"catalyst":""},{"name":"Maintaining carbapenem therapy","genericName":"Maintaining carbapenem therapy","slug":"maintaining-carbapenem-therapy","phase":"marketed","mechanism":"Carbapenem antibiotics inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins and disrupting peptidoglycan cross-linking.","indications":["Serious bacterial infections (gram-positive, gram-negative, and anaerobic)","Hospital-acquired infections","Intra-abdominal infections","Respiratory tract infections","Urinary tract infections"],"catalyst":""},{"name":"Medicinal air","genericName":"Medicinal air","slug":"medicinal-air","phase":"phase_3","mechanism":"Medicinal air delivers therapeutic oxygen and/or other gaseous components to improve oxygenation and respiratory function in patients with hypoxemia or respiratory compromise.","indications":["Hypoxemia requiring supplemental oxygen therapy","Respiratory insufficiency in hospitalized patients"],"catalyst":""},{"name":"Metatranscriptomic","genericName":"Metatranscriptomic","slug":"metatranscriptomic","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Metformin and FSHr","genericName":"Metformin and FSHr","slug":"metformin-and-fshr","phase":"marketed","mechanism":"This combination uses metformin to improve insulin sensitivity and metabolic parameters while FSHr (follicle-stimulating hormone receptor) agonism promotes follicular development for fertility enhancement.","indications":["Infertility in women with PCOS or insulin resistance"],"catalyst":""},{"name":"Mycophenolate mofetil,methotrexate","genericName":"Mycophenolate mofetil,methotrexate","slug":"mycophenolate-mofetil-methotrexate","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Nicotinamide treatment","genericName":"Nicotinamide treatment","slug":"nicotinamide-treatment","phase":"phase_3","mechanism":"Nicotinamide replenishes NAD+ cofactor pools to support cellular energy metabolism and DNA repair pathways.","indications":["Phase 3 indication not publicly specified; likely dermatologic or metabolic condition based on nicotinamide's known clinical applications"],"catalyst":""},{"name":"Normacol","genericName":"Normacol","slug":"normacol","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Novel strategy Aspirin","genericName":"Novel strategy Aspirin","slug":"novel-strategy-aspirin","phase":"marketed","mechanism":"Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes to reduce platelet aggregation and inflammation.","indications":["Cardiovascular disease prevention (secondary prevention post-myocardial infarction or stroke)","Acute coronary syndrome","Mild to moderate pain and fever","Inflammatory conditions"],"catalyst":""},{"name":"Oral Anticoagulant, Direct-Acting","genericName":"Oral Anticoagulant, Direct-Acting","slug":"oral-anticoagulant-direct-acting","phase":"phase_3","mechanism":"Direct-acting oral anticoagulants inhibit specific clotting factors (typically Factor Xa or thrombin) to prevent blood clot formation.","indications":["Atrial fibrillation for stroke prevention","Venous thromboembolism prevention and treatment"],"catalyst":""},{"name":"Oral Prednisone","genericName":"Oral Prednisone","slug":"oral-prednisone","phase":"marketed","mechanism":"Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors in cells.","indications":["Adrenocortical insufficiency","Rheumatoid arthritis","Systemic lupus erythematosus","Polymyalgia rheumatica","Giant cell arteritis"],"catalyst":""},{"name":"Orally antibacterial agents","genericName":"Orally antibacterial agents","slug":"orally-antibacterial-agents","phase":"marketed","mechanism":"Orally administered antibacterial agents work by inhibiting bacterial growth and survival through various mechanisms such as cell wall disruption, protein synthesis inhibition, or DNA/RNA interference.","indications":["Bacterial infections (oral formulations for systemic or localized infections)"],"catalyst":""},{"name":"Oxytocin 2 mIU/mL","genericName":"Oxytocin 2 mIU/mL","slug":"oxytocin-2-miu-ml","phase":"marketed","mechanism":"Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection.","indications":["Induction or augmentation of labor","Control of postpartum hemorrhage","Promotion of milk letdown in lactation"],"catalyst":""},{"name":"Oxytocin 4 mIU/mL","genericName":"Oxytocin 4 mIU/mL","slug":"oxytocin-4-miu-ml","phase":"marketed","mechanism":"Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection.","indications":["Induction or augmentation of labor","Management of postpartum hemorrhage","Promotion of milk letdown in lactation"],"catalyst":""},{"name":"PCV chemotherapy alone","genericName":"PCV chemotherapy alone","slug":"pcv-chemotherapy-alone","phase":"phase_3","mechanism":"PCV chemotherapy involves the combination of three chemotherapy drugs: methotrexate, cyclophosphamide, and vincristine, which work together to kill rapidly dividing cancer cells.","indications":["Acute lymphoblastic leukemia","Hodgkin lymphoma"],"catalyst":""},{"name":"Patch, Nicotine","genericName":"Patch, Nicotine","slug":"patch-nicotine","phase":"marketed","mechanism":"Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system to reduce cravings and withdrawal symptoms during smoking cessation.","indications":["Smoking cessation aid"],"catalyst":""},{"name":"Pfizer","genericName":"Pfizer","slug":"pfizer","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Piperacillin/tazobactam or temocillin","genericName":"Piperacillin/tazobactam or temocillin","slug":"piperacillin-tazobactam-or-temocillin","phase":"phase_3","mechanism":"Piperacillin/tazobactam and temocillin are beta-lactam antibiotics that inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, with tazobactam providing beta-lactamase inhibition to overcome resistance.","indications":["Serious gram-negative and gram-positive bacterial infections (piperacillin/tazobactam)","Aerobic gram-negative infections including Enterobacteriaceae (temocillin)","Hospital-acquired and nosocomial infections"],"catalyst":""},{"name":"Placebo (Ambrisentan-matching)","genericName":"Placebo (Ambrisentan-matching)","slug":"placebo-ambrisentan-matching","phase":"phase_3","mechanism":"This is a placebo control matching the appearance and administration of ambrisentan, an endothelin receptor antagonist, with no active pharmacological effect.","indications":["Control arm in phase 3 clinical trial of ambrisentan for pulmonary arterial hypertension"],"catalyst":""},{"name":"Placebo (NaCl 0.9 % solution)","genericName":"Placebo (NaCl 0.9 % solution)","slug":"placebo-nacl-0-9-solution","phase":"marketed","mechanism":"Normal saline (0.9% NaCl solution) is an inert isotonic fluid that serves as a physiological vehicle for drug delivery or fluid replacement with no active pharmacological mechanism.","indications":["Placebo control in clinical trials","Vehicle for parenteral drug delivery"],"catalyst":""},{"name":"Placebo (NaCl 0.9%)","genericName":"Placebo (NaCl 0.9%)","slug":"placebo-nacl-0-9","phase":"marketed","mechanism":"Normal saline (0.9% NaCl) is an inert isotonic solution that serves as a physiological vehicle for drug delivery or fluid replacement with no active pharmacological mechanism.","indications":["Placebo control in clinical trials","Fluid and electrolyte replacement (when used therapeutically)"],"catalyst":""},{"name":"Placebo (for Aspirin 300)","genericName":"Placebo (for Aspirin 300)","slug":"placebo-for-aspirin-300","phase":"phase_3","mechanism":"Placebo has no active pharmacological mechanism; it serves as an inert control in clinical trials to establish baseline efficacy and safety of the active comparator (Aspirin 300).","indications":["Control arm in Phase 3 trial comparing Aspirin 300 efficacy and safety"],"catalyst":""},{"name":"Placebo (tablets per os)","genericName":"Placebo (tablets per os)","slug":"placebo-tablets-per-os","phase":"phase_3","mechanism":"Placebo produces no pharmacological effect and serves as an inert control in clinical trials.","indications":["Control arm in phase 3 clinical trials (specific indication depends on parent trial)"],"catalyst":""},{"name":"Placebo 100 (for Aspirin 100)","genericName":"Placebo 100 (for Aspirin 100)","slug":"placebo-100-for-aspirin-100","phase":"phase_3","mechanism":"This is a placebo control formulation used in clinical trials to compare against Aspirin 100 mg.","indications":["Control arm in clinical trials comparing Aspirin 100 mg efficacy"],"catalyst":""},{"name":"Placebo Formula 515","genericName":"Placebo Formula 515","slug":"placebo-formula-515","phase":"marketed","mechanism":"Placebo Formula 515 is an inert formulation with no active pharmaceutical ingredient, producing therapeutic effects through placebo mechanisms.","indications":["Clinical research control comparator","Conditions responsive to placebo effect"],"catalyst":""},{"name":"Placebo filling","genericName":"Placebo filling","slug":"placebo-filling","phase":"phase_3","mechanism":"A placebo filling serves as an inert control substance in clinical trials to establish baseline efficacy and safety comparisons.","indications":[],"catalyst":""},{"name":"Placebo in addition to UDCA therapy","genericName":"Placebo in addition to UDCA therapy","slug":"placebo-in-addition-to-udca-therapy","phase":"phase_3","mechanism":"Placebo does not have a known mechanism of action.","indications":["Primary biliary cholangitis"],"catalyst":""},{"name":"Placebo of Levosimendan","genericName":"Placebo of Levosimendan","slug":"placebo-of-levosimendan","phase":"phase_3","mechanism":"This is a placebo control arm and contains no active drug; it serves as a comparator in clinical trials of levosimendan.","indications":["Placebo control in phase 3 trials of levosimendan for acute decompensated heart failure"],"catalyst":""},{"name":"Placebo of NICOTINE Transdermal patch","genericName":"Placebo of NICOTINE Transdermal patch","slug":"placebo-of-nicotine-transdermal-patch","phase":"phase_3","mechanism":"This is a placebo control formulation containing no active nicotine, used as a comparator in clinical trials to assess the true efficacy of nicotine transdermal patches.","indications":["Placebo control for nicotine replacement therapy trials in smoking cessation"],"catalyst":""},{"name":"Placebo of Nifedipine","genericName":"Placebo of Nifedipine","slug":"placebo-of-nifedipine","phase":"phase_3","mechanism":"Nifedipine is a calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.","indications":["Hypertension","Angina pectoris"],"catalyst":""},{"name":"Placebo of Pioglitazone","genericName":"Placebo of Pioglitazone","slug":"placebo-of-pioglitazone","phase":"phase_3","mechanism":"This is a placebo control arm in a clinical trial and contains no active pharmaceutical ingredient.","indications":["Control arm in Phase 3 clinical trial of pioglitazone (indication dependent on parent trial)"],"catalyst":""},{"name":"Placebo of ofloxacine","genericName":"Placebo of ofloxacine","slug":"placebo-of-ofloxacine","phase":"phase_3","mechanism":"This drug is a placebo, meaning it has no active pharmacological effect.","indications":["Bacterial conjunctivitis"],"catalyst":""},{"name":"Placebo-rituximab","genericName":"Placebo-rituximab","slug":"placebo-rituximab","phase":"phase_3","mechanism":"Rituximab is a monoclonal antibody that targets and depletes CD20-positive B cells.","indications":["Non-Hodgkin's lymphoma","Chronic lymphocytic leukemia"],"catalyst":""},{"name":"Prednisone (Cortancyl®)","genericName":"Prednisone (Cortancyl®)","slug":"prednisone-cortancyl","phase":"phase_3","mechanism":"Prednisone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties.","indications":["Rheumatoid arthritis","Multiple sclerosis","Asthma","Allergic reactions","Urticaria"],"catalyst":""},{"name":"Prednisone - Azathioprine","genericName":"Prednisone - Azathioprine","slug":"prednisone-azathioprine","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Pregnancy test","genericName":"Pregnancy test","slug":"pregnancy-test","phase":"marketed","mechanism":"A pregnancy test detects human chorionic gonadotropin (hCG) hormone in urine or blood to confirm pregnancy.","indications":["Detection of pregnancy"],"catalyst":""},{"name":"Prospective","genericName":"Prospective","slug":"prospective","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Pyrimethamine/Sulfadiazine","genericName":"Pyrimethamine/Sulfadiazine","slug":"pyrimethamine-sulfadiazine","phase":"phase_3","mechanism":"Pyrimethamine and sulfadiazine work synergistically to inhibit folate metabolism in parasites and bacteria, blocking nucleotide synthesis and preventing microbial replication.","indications":["Toxoplasmosis, including cerebral toxoplasmosis in immunocompromised patients","Toxoplasma gondii infection prophylaxis and treatment"],"catalyst":""},{"name":"RIAMET (artemether + LUMEFANTRIN combination)","genericName":"RIAMET (artemether + LUMEFANTRIN combination)","slug":"riamet-artemether-lumefantrin-combination","phase":"marketed","mechanism":"Riamet combines artemether, a fast-acting antimalarial, with lumefantrine, a longer-acting partner, to provide a synergistic effect against Plasmodium falciparum.","indications":[],"catalyst":""},{"name":"RIFINAH ©","genericName":"RIFINAH ©","slug":"rifinah","phase":"phase_3","mechanism":"Rifinah is an antitubercular medication that works by inhibiting the synthesis of mycolic acid in Mycobacterium tuberculosis.","indications":["Treatment of tuberculosis"],"catalyst":""},{"name":"Radiotherapy","genericName":"Radiotherapy","slug":"radiotherapy","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Radiotherapy+PCV chemotherapy","genericName":"Radiotherapy+PCV chemotherapy","slug":"radiotherapy-pcv-chemotherapy","phase":"phase_3","mechanism":"Radiotherapy works by damaging the DNA of cancer cells, while PCV chemotherapy targets rapidly dividing cells with a combination of drugs.","indications":["Glioblastoma"],"catalyst":""},{"name":"Recipients","genericName":"Recipients","slug":"recipients","phase":"phase_2","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Restrictive Red blood cell transfusion","genericName":"Restrictive Red blood cell transfusion","slug":"restrictive-red-blood-cell-transfusion","phase":"phase_3","mechanism":"A clinical strategy that limits red blood cell transfusions to lower hemoglobin thresholds, reducing unnecessary transfusion exposure while maintaining adequate oxygen delivery.","indications":["Perioperative blood management in surgical patients","Critical illness requiring red blood cell transfusion support"],"catalyst":""},{"name":"Rituximab (Arm A)","genericName":"Rituximab (Arm A)","slug":"rituximab-arm-a","phase":"phase_3","mechanism":"Rituximab is a monoclonal antibody that binds to CD20 on B cells, leading to their depletion through antibody-dependent cellular cytotoxicity and direct apoptosis.","indications":["B-cell non-Hodgkin's lymphoma","Chronic lymphocytic leukemia","Rheumatoid arthritis","Granulomatosis with polyangiitis","Microscopic polyangiitis"],"catalyst":""},{"name":"Rituximab, Methotrexate, Temozolomide","genericName":"Rituximab, Methotrexate, Temozolomide","slug":"rituximab-methotrexate-temozolomide","phase":"phase_3","mechanism":"Rituximab is a monoclonal antibody that targets and depletes CD20-positive B cells, while Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, and Temozolomide is an alkylating agent that cross-links DNA.","indications":["Non-Hodgkin's lymphoma","Rheumatoid arthritis","Glioblastoma multiforme"],"catalyst":""},{"name":"SIR-Sphere","genericName":"SIR-Sphere","slug":"sir-sphere","phase":"phase_3","mechanism":"SIR-Sphere delivers yttrium-90 radiation directly to liver tumors via microspheres injected into the hepatic artery.","indications":["Hepatocellular carcinoma","Liver metastases"],"catalyst":""},{"name":"Sham-transplantation (placebo)","genericName":"Sham-transplantation (placebo)","slug":"sham-transplantation-placebo","phase":"phase_3","mechanism":"Sham-transplantation, also known as placebo treatment, does not involve any actual therapeutic intervention.","indications":["Treatment of various conditions in a clinical trial setting to compare with actual treatment"],"catalyst":""},{"name":"Short antibiotic treatment","genericName":"Short antibiotic treatment","slug":"short-antibiotic-treatment","phase":"phase_3","mechanism":"This drug targets bacterial cell wall synthesis to inhibit bacterial growth.","indications":["Community-acquired pneumonia","Skin and soft tissue infections"],"catalyst":""},{"name":"Shortened duration of antifungal therapy","genericName":"Shortened duration of antifungal therapy","slug":"shortened-duration-of-antifungal-therapy","phase":"phase_3","mechanism":"Shortened duration of antifungal therapy is achieved by reducing the time required to treat fungal infections.","indications":["Treatment of fungal infections"],"catalyst":""},{"name":"Spiramycine","genericName":"Spiramycine","slug":"spiramycine","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Standard hyponatremia treatment","genericName":"Standard hyponatremia treatment","slug":"standard-hyponatremia-treatment","phase":"phase_3","mechanism":"Standard hyponatremia treatment typically involves fluid restriction and/or sodium supplementation to restore normal serum sodium levels.","indications":["Hyponatremia (symptomatic or severe)"],"catalyst":""},{"name":"Stool collect","genericName":"Stool collect","slug":"stool-collect","phase":"marketed","mechanism":"Stool collect is a diagnostic collection device used to obtain fecal samples for laboratory analysis.","indications":["Stool sample collection for diagnostic laboratory testing"],"catalyst":""},{"name":"Sulfate, Magnesium","genericName":"Sulfate, 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