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Abiraterone acetate escalated dose
Abiraterone acetate escalated dose is a CYP17A1 inhibitor Small molecule drug developed by Assistance Publique - Hôpitaux de Paris. It is currently in Phase 2 development for Metastatic castration-resistant prostate cancer, Castration-sensitive prostate cancer (in combination with androgen deprivation therapy).
Abiraterone acetate is a CYP17A1 inhibitor that blocks androgen synthesis, reducing testosterone production to treat androgen-dependent cancers.
Abiraterone acetate is a CYP17A1 inhibitor that blocks androgen synthesis, reducing testosterone production to treat androgen-dependent cancers. Used for Metastatic castration-resistant prostate cancer, Castration-sensitive prostate cancer (in combination with androgen deprivation therapy).
At a glance
| Generic name | Abiraterone acetate escalated dose |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | CYP17A1 inhibitor |
| Target | CYP17A1 (17α-hydroxylase/17,20-lyase) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Abiraterone acetate inhibits the enzyme 17α-hydroxylase/17,20-lyase (CYP17A1), which is critical for androgen biosynthesis in the adrenal glands and tumor cells. By blocking this enzyme, it reduces circulating and intratumoral testosterone levels, thereby suppressing androgen receptor signaling in hormone-sensitive cancers. The escalated dose regimen aims to achieve higher drug exposure for potentially improved efficacy in advanced disease.
Approved indications
- Metastatic castration-resistant prostate cancer
- Castration-sensitive prostate cancer (in combination with androgen deprivation therapy)
Common side effects
- Hypokalemia
- Hypertension
- Fluid retention/edema
- Fatigue
- Diarrhea
- Nausea
- Elevated liver enzymes
Key clinical trials
- A Study of JNJ-78278343 in Combination With Either JNJ-63723283 (Cetrelimab), Taxane Chemotherapy, or Androgen Receptor Pathway Inhibitors for Metastatic Prostate Cancer (PHASE1)
- Study of Dose Escalation of Abiraterone Actetate in Prostate Cancer (PHASE2)
- ARN 509 Plus Everolimus in Men With Progressive Metastatic Castration-Resistant Prostate Cancer After Treatment With Abiraterone Acetate (PHASE1)
- A Phase II Study of Increased-Dose Abiraterone Acetate in Patients With Castration Resistant Prostate Cancer (PHASE2)
- Abiraterone Acetate Dose-Escalation Study in Hormone Refractory Prostate Cancer (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Abiraterone acetate escalated dose CI brief — competitive landscape report
- Abiraterone acetate escalated dose updates RSS · CI watch RSS
- Assistance Publique - Hôpitaux de Paris portfolio CI
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Related
- Drug class: All CYP17A1 inhibitor drugs
- Target: All drugs targeting CYP17A1 (17α-hydroxylase/17,20-lyase)
- Manufacturer: Assistance Publique - Hôpitaux de Paris — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic castration-resistant prostate cancer
- Indication: Drugs for Castration-sensitive prostate cancer (in combination with androgen deprivation therapy)
- Compare: Abiraterone acetate escalated dose vs similar drugs
- Pricing: Abiraterone acetate escalated dose cost, discount & access