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general anesthesia (fentanyl)
Fentanyl is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation.
Fentanyl is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. Used for General anesthesia induction and maintenance, Perioperative analgesia, Sedation in critically ill patients.
At a glance
| Generic name | general anesthesia (fentanyl) |
|---|---|
| Sponsor | Rambam Health Care Campus |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Fentanyl activates mu opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing profound analgesia and sedation suitable for general anesthesia induction and maintenance. It is approximately 50–100 times more potent than morphine and has a rapid onset and relatively short duration of action, making it ideal for perioperative use.
Approved indications
- General anesthesia induction and maintenance
- Perioperative analgesia
- Sedation in critically ill patients
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Chest wall rigidity
- Nausea and vomiting
- Pruritus
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Cardiac Index and General Anesthesia Without Opioid. (PHASE2, PHASE3)
- Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery (NA)
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- Prospective IR-led Sedation Feasibility (PHASE1, PHASE2)
- General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound (NA)
- Comparison of Gastric Insufflation Volume Between LarySeal Pro and Ambu AuraGain Using Ultrasonography In Pediatric Patients Undergoing General Anesthesia With Controlled Ventilation. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- general anesthesia (fentanyl) CI brief — competitive landscape report
- general anesthesia (fentanyl) updates RSS · CI watch RSS
- Rambam Health Care Campus portfolio CI