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Opioid Anesthetics
Opioid anesthetics bind to opioid receptors in the central nervous system to produce analgesia, sedation, and unconsciousness for surgical procedures.
Opioid anesthetics bind to opioid receptors in the central nervous system to produce analgesia, sedation, and unconsciousness for surgical procedures. Used for Induction and maintenance of general anesthesia, Analgesia during surgical procedures.
At a glance
| Generic name | Opioid Anesthetics |
|---|---|
| Also known as | OA, IV fentanyl, Opioid-based regimen, Opioid-based anesthetic, Opioid consumption during general anesthesia |
| Sponsor | Kasr El Aini Hospital |
| Drug class | Opioid agonist |
| Target | Mu opioid receptor (primary); delta and kappa opioid receptors (secondary) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Opioid anesthetics work by activating mu, delta, and kappa opioid receptors throughout the brain and spinal cord, suppressing pain signal transmission and producing profound analgesia combined with sedative and hypnotic effects. Common agents in this class (such as remifentanil, sufentanil, and fentanyl) are used as primary anesthetic agents or adjuncts during general anesthesia to provide rapid onset, titratable depth of anesthesia, and quick recovery.
Approved indications
- Induction and maintenance of general anesthesia
- Analgesia during surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Chest wall rigidity
Key clinical trials
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Virtual Reality for Postoperative Recovery After Major Abdominal Surgery (NA)
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Anterior QLB for PCNL (NA)
- Analgesic Techniques for Robotic Prostatectomy Procedures (NA)
- Erector Spinae Plane Block for Pain Control After Open Abdominal Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Opioid Anesthetics CI brief — competitive landscape report
- Opioid Anesthetics updates RSS · CI watch RSS
- Kasr El Aini Hospital portfolio CI