What is PBO-N/PBO-B used for?

PBO-N/PBO-B is indicated for Moderate to severe pain.

Who makes PBO-N/PBO-B?

PBO-N/PBO-B is developed by Alkermes, Inc..

What are the side effects of PBO-N/PBO-B?

Common side effects include Nausea, Dizziness, Headache.

Last reviewed 2026-04-23 · How we verify

PBO-N/PBO-B

Alkermes, Inc. · Phase 3 active Small molecule

PBO-N/PBO-B is a partial opioid agonist.

PBO-N/PBO-B is a partial opioid agonist. Used for Moderate to severe pain.

At a glance

Generic name	PBO-N/PBO-B
Sponsor	Alkermes, Inc.
Drug class	partial opioid agonist
Target	mu-opioid receptor
Modality	Small molecule
Therapeutic area	Pain
Phase	Phase 3

Mechanism of action

PBO-N/PBO-B works by activating opioid receptors in the brain, producing analgesia with reduced risk of respiratory depression compared to full opioid agonists.

Approved indications

Moderate to severe pain

Common side effects

Nausea
Dizziness
Headache

Key clinical trials

Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension) (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

PBO-N/PBO-B CI brief — competitive landscape report
PBO-N/PBO-B updates RSS · CI watch RSS
Alkermes, Inc. portfolio CI