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Post-operative
This drug works by inhibiting the action of certain neurotransmitters in the brain.
This drug works by inhibiting the action of certain neurotransmitters in the brain. Used for Post-operative pain management.
At a glance
| Generic name | Post-operative |
|---|---|
| Also known as | Methadone boluses administered by IV-PCA pump |
| Sponsor | Pontificia Universidad Catolica de Chile |
| Drug class | Opioid |
| Target | Mu opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
By blocking these neurotransmitters, the drug reduces the transmission of pain signals to the brain, providing relief from post-operative pain. This is achieved through a complex interplay of molecular mechanisms involving various ion channels and receptors. The exact molecular pathways involved are still being studied.
Approved indications
- Post-operative pain management
Common side effects
- Nausea
- Vomiting
- Dizziness
- Constipation
- Respiratory depression
Key clinical trials
- Immediate Restoration of a New Implant With High Primary Stability (NA)
- Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy (PHASE3)
- Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma (PHASE3)
- Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp. (NA)
- Project Tendura: The Impact of Blood Flow Restriction Resistance Training (BFR-RT) in Patients With Achilles Tendon Rupture (ATR) Repair (NA)
- Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A) (PHASE2)
- Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma (PHASE1)
- External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |