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Pharmacologic Pain Management
This drug modulates the activity of the mu-opioid receptor to reduce pain perception.
This drug modulates the activity of the mu-opioid receptor to reduce pain perception. Used for Moderate to severe pain.
At a glance
| Generic name | Pharmacologic Pain Management |
|---|---|
| Also known as | Oxycodone Hydrochloride, Hydrocodone Bitartrate and Acetaminophen, Morphine Sulfate, Methadone Hydrochloride, Buprenorphine |
| Sponsor | University of California, San Francisco |
| Drug class | Opioid |
| Target | mu-opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
By binding to the mu-opioid receptor, the drug activates a signaling cascade that ultimately leads to the reduction of pain transmission in the central nervous system. This results in a decrease in the perception of pain, providing relief to patients suffering from moderate to severe pain.
Approved indications
- Moderate to severe pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Vomiting
- Headache
- Somnolence
- Fatigue
- Dry mouth
- Itching
- Rash
Key clinical trials
- Induction of Labor by Cervical Ripening and Transcutaneous Electrical Nerve Stimulation (TENS) (NA)
- Effects of Local Ketamine in Orthognathic Procedures (NA)
- Comparison of Virtual Reality and Stress Ball for Pain During Episiotomy Repair (NA)
- Weighted Blanket Use for Adults With Chronic Pain: A Pilot Study (NA)
- Virtual Reality for Postoperative Recovery After Major Abdominal Surgery (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Preoperative Opioid Tapering Before Spine Surgery (NA)
- Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking (PHASE1, PHASE2)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |