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Tramadol HCl/Acetaminophen IR
Tramadol HCl/Acetaminophen IR is a combination of a centrally acting opioid analgesic and a non-opioid analgesic that works by affecting the central nervous system to relieve pain.
Tramadol HCl/Acetaminophen IR is a combination of a centrally acting opioid analgesic and a non-opioid analgesic that works by affecting the central nervous system to relieve pain. Used for Moderate to moderately severe pain, Severe pain.
At a glance
| Generic name | Tramadol HCl/Acetaminophen IR |
|---|---|
| Also known as | Ultracet |
| Sponsor | Janssen Korea, Ltd., Korea |
| Drug class | Opioid agonist and non-opioid analgesic combination |
| Target | mu-opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Tramadol HCl, an opioid agonist, binds to mu-opioid receptors in the brain, while acetaminophen, a non-opioid analgesic, works by inhibiting the production of prostaglandins, which are chemicals that cause pain and inflammation.
Approved indications
- Moderate to moderately severe pain
- Severe pain
Common side effects
- Nausea
- Dizziness
- Headache
- Vomiting
- Constipation
- Diarrhea
- Fatigue
- Sleep disorder
- Sweating
- Yawning
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |