Last reviewed · How we verify
Preservative-free epidural morphine
Morphine binds to opioid receptors in the spinal cord and brain to block pain signal transmission and provide analgesia.
Morphine binds to opioid receptors in the spinal cord and brain to block pain signal transmission and provide analgesia. Used for Acute postoperative pain, Chronic cancer pain, Chronic non-cancer pain.
At a glance
| Generic name | Preservative-free epidural morphine |
|---|---|
| Also known as | Morphine, Epidural Narcotics |
| Sponsor | Mount Sinai Hospital, Canada |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that acts on opioid receptors in the central nervous system. When administered epidurally, it reaches opioid receptors in the spinal cord at lower systemic doses than oral or intravenous administration, providing potent analgesia with reduced systemic side effects. The preservative-free formulation minimizes neurotoxicity and irritation to neural tissue.
Approved indications
- Acute postoperative pain
- Chronic cancer pain
- Chronic non-cancer pain
Common side effects
- Pruritus
- Nausea and vomiting
- Urinary retention
- Respiratory depression
- Hypotension
- Headache
Key clinical trials
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications. (EARLY_PHASE1)
- Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy (PHASE2)
- Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery (PHASE4)
- Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery (PHASE4)
- Dosage of Epidural Morphine in Elderly Patients (PHASE4)
- 2 Dose Neuraxial Morphine for Prevention of PDPH (PHASE4)
- Evaluation of the Typical Spinal Block During Cesarean Delivery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Preservative-free epidural morphine CI brief — competitive landscape report
- Preservative-free epidural morphine updates RSS · CI watch RSS
- Mount Sinai Hospital, Canada portfolio CI