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Standard Opioid
Standard opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and produce analgesia.
Standard opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and produce analgesia. Used for Moderate to severe acute pain, Chronic pain (cancer-related and non-cancer pain).
At a glance
| Generic name | Standard Opioid |
|---|---|
| Sponsor | Prisma Health-Upstate |
| Drug class | Opioid analgesic |
| Target | Mu opioid receptor (primary); delta and kappa opioid receptors (secondary) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Opioids are agonists at mu, delta, and kappa opioid receptors, with mu-receptor activation being the primary mechanism for analgesia and euphoria. By binding to these G-protein coupled receptors, opioids inhibit neurotransmitter release and hyperpolarize neurons, reducing pain signal transmission. They also modulate descending pain pathways in the brainstem and spinal cord.
Approved indications
- Moderate to severe acute pain
- Chronic pain (cancer-related and non-cancer pain)
Common side effects
- Constipation
- Nausea
- Drowsiness/sedation
- Dizziness
- Respiratory depression
- Dependence/addiction
Key clinical trials
- Opioid, HIV and Immune System (PHASE4)
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections (PHASE2)
- NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty (NA)
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery (NA)
- Text Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids (NA)
- Virtual Reality for Postoperative Recovery After Major Abdominal Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Standard Opioid CI brief — competitive landscape report
- Standard Opioid updates RSS · CI watch RSS
- Prisma Health-Upstate portfolio CI