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Opioid administration oxycodone
Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception and provide analgesia. Used for Moderate to severe acute pain, Moderate to severe chronic pain.
At a glance
| Generic name | Opioid administration oxycodone |
|---|---|
| Also known as | Epidural Opioid |
| Sponsor | KK Women's and Children's Hospital |
| Drug class | Opioid analgesic |
| Target | Mu opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Oxycodone is a semi-synthetic opioid agonist that binds primarily to mu (μ) opioid receptors in the brain and spinal cord, inhibiting pain signal transmission and modulating pain perception. It also has activity at delta (δ) and kappa (κ) opioid receptors. The drug crosses the blood-brain barrier and produces its analgesic effects through central nervous system depression.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Vomiting
- Respiratory depression
- Dependence/addiction risk
Key clinical trials
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty (PHASE4)
- Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use (PHASE1)
- Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy (NA)
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Effectiveness of Percutaneous Neuromodulation vs Pharmacological Treatment in Cancer Patients With Anterior Knee Pain (NA)
- A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Opioid administration oxycodone CI brief — competitive landscape report
- Opioid administration oxycodone updates RSS · CI watch RSS
- KK Women's and Children's Hospital portfolio CI