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MS Contin
MS Contin is a sustained-release formulation of morphine sulfate that binds to opioid receptors in the central nervous system to reduce pain perception.
MS Contin is a sustained-release formulation of morphine sulfate that binds to opioid receptors in the central nervous system to reduce pain perception. Used for Moderate to severe chronic pain in opioid-tolerant patients, Cancer pain.
At a glance
| Generic name | MS Contin |
|---|---|
| Also known as | oxycodone, morphine |
| Sponsor | National Institute of Nursing Research (NINR) |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that decreases pain signaling by binding to opioid receptors in the brain and spinal cord. The sustained-release formulation provides continuous drug delivery over 8-12 hours, allowing for less frequent dosing compared to immediate-release formulations. This mechanism makes it suitable for chronic pain management in opioid-tolerant patients.
Approved indications
- Moderate to severe chronic pain in opioid-tolerant patients
- Cancer pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Vomiting
- Respiratory depression
- Dependence/tolerance
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma (PHASE3)
- Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (PHASE3)
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Comparison of Non-Invasive Respiratory Monitoring System (RMS)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Analgesic Effects of Intrathecal Morphine and Transversalis Plane Block After Cesarean Delivery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- MS Contin CI brief — competitive landscape report
- MS Contin updates RSS · CI watch RSS
- National Institute of Nursing Research (NINR) portfolio CI