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Morphine intravenous
Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria.
Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria. Used for Acute moderate to severe pain, Postoperative pain, Cancer pain.
At a glance
| Generic name | Morphine intravenous |
|---|---|
| Also known as | Morphine and patient controlled analgesia |
| Sponsor | Charles University, Czech Republic |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that crosses the blood-brain barrier and acts on opioid receptors in the brain, spinal cord, and peripheral tissues. This binding modulates pain perception, reduces anxiety, and produces sedation. The intravenous formulation provides rapid onset of action for acute pain management.
Approved indications
- Acute moderate to severe pain
- Postoperative pain
- Cancer pain
- Myocardial infarction-associated pain
Common side effects
- Respiratory depression
- Sedation
- Nausea and vomiting
- Constipation
- Pruritus
- Hypotension
- Dependence and tolerance
Key clinical trials
- Comparison of Intrathecal Morphine and Rectus Sheath Block for Postoperative Pain Management After Lower Abdominal Surgery With Midline Incision (NA)
- Effect of CYP2D6 on Perioperative Analgesia of Oxycodone in Elderly Patients
- A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Ocrelizumab in Participants With Relapsing Multiple Sclerosis and Primary Progressive Multiple Sclerosis (PHASE4)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- A Study Evaluating the Safety and Efficacy of KITE-363 in Relapsed/Refractory Autoimmune Neurologic Diseases (PHASE1)
- E7 TCR T Cells for Human Papillomavirus-Associated Cancers (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |