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Spinal Hydromorphone
Spinal hydromorphone is an opioid analgesic that binds to opioid receptors in the spinal cord to block pain signal transmission.
Spinal hydromorphone is an opioid analgesic that binds to opioid receptors in the spinal cord to block pain signal transmission. Used for Chronic pain management via intrathecal delivery, Cancer pain, Post-operative pain.
At a glance
| Generic name | Spinal Hydromorphone |
|---|---|
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Drug class | Opioid analgesic |
| Target | Mu opioid receptor (primary), delta and kappa opioid receptors |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Hydromorphone is a semi-synthetic opioid agonist that acts on mu, delta, and kappa opioid receptors. When administered intrathecally (directly into the spinal fluid), it provides potent analgesia by inhibiting pain neurotransmission at the spinal level, allowing for lower systemic doses and reduced systemic side effects compared to oral or parenteral administration.
Approved indications
- Chronic pain management via intrathecal delivery
- Cancer pain
- Post-operative pain
Common side effects
- Respiratory depression
- Pruritus
- Nausea and vomiting
- Urinary retention
- Constipation
- Hypotension
Key clinical trials
- Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Opioid-Sparing Joint Replacement (PHASE3)
- A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair (PHASE4)
- Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery (NA)
- A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery (NA)
- Analgesic Effect of Ropivacaine Combined With Hydromorphone for CSEA After Total Knee Arthroplasty (NA)
- Comparison of Epidural and TAP Block in Abdominal Surgery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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