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Standard Care morphine hydrochloride
Morphine hydrochloride binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.
Morphine hydrochloride binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation. Used for Moderate to severe acute pain, Moderate to severe chronic pain, Dyspnea relief in palliative care.
At a glance
| Generic name | Standard Care morphine hydrochloride |
|---|---|
| Also known as | morphine hydrochloride |
| Sponsor | Centre Hospitalier Universitaire de Nīmes |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that decreases pain perception by acting on opioid receptors in the brain and spinal cord. It also produces sedation, euphoria, and respiratory depression through central nervous system effects. The drug is a naturally occurring alkaloid from the opium poppy and remains a gold-standard opioid analgesic for moderate to severe pain.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
- Dyspnea relief in palliative care
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Respiratory depression
- Pruritus
- Vomiting
Key clinical trials
- Anesthetics and Analgesics in Children
- An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service (PHASE3)
- Oxycodone Versus Intravenous Morphine for Postoperative Analgesia After Hip Surgery (PHASE4)
- Multimodal Analgesia Effect on Post Surgical Patient (PHASE4)
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
- Impact of Opioid Avoidance Protocol for ACL Reconstruction
- Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
- Postoperative Pain Control in Septum and Sinus Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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