{"id":"standard-care-morphine-hydrochloride","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Constipation"},{"rate":"20-30","effect":"Nausea"},{"rate":"20-30","effect":"Drowsiness"},{"rate":"10-20","effect":"Dizziness"},{"rate":null,"effect":"Respiratory depression"},{"rate":"10-15","effect":"Pruritus"},{"rate":"10-20","effect":"Vomiting"}]},"_chembl":{"chemblId":"CHEMBL556578","moleculeType":"Small molecule","molecularWeight":"321.80"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that decreases pain perception by acting on opioid receptors in the brain and spinal cord. It also produces sedation, euphoria, and respiratory depression through central nervous system effects. The drug is a naturally occurring alkaloid from the opium poppy and remains a gold-standard opioid analgesic for moderate to severe pain.","oneSentence":"Morphine hydrochloride binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:03.249Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Moderate to severe chronic pain"},{"name":"Dyspnea relief in palliative care"}]},"trialDetails":[{"nctId":"NCT03427736","phase":"","title":"Anesthetics and Analgesics in Children","status":"RECRUITING","sponsor":"Chi Dang Hornik","startDate":"2018-12-13","conditions":"Anesthesia, Pain","enrollment":460},{"nctId":"NCT07296770","phase":"PHASE3","title":"An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery","enrollment":126},{"nctId":"NCT01536301","phase":"PHASE4","title":"Oxycodone Versus Intravenous Morphine for Postoperative Analgesia After Hip Surgery","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2012-06","conditions":"Arthroplasty, Replacement, Hip","enrollment":246},{"nctId":"NCT04240626","phase":"PHASE4","title":"Multimodal Analgesia Effect on Post Surgical Patient","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, Davis","startDate":"2021-01-20","conditions":"Obesity, Morbid, Surgery, Bariatric Surgery Candidate","enrollment":60},{"nctId":"NCT04278404","phase":"","title":"Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)","status":"RECRUITING","sponsor":"Duke University","startDate":"2020-03-05","conditions":"Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children","enrollment":5000},{"nctId":"NCT06340932","phase":"","title":"Impact of Opioid Avoidance Protocol for ACL Reconstruction","status":"COMPLETED","sponsor":"Matthew Varacallo","startDate":"2024-04-27","conditions":"ACL Tear, Post Operative Pain","enrollment":32},{"nctId":"NCT01431326","phase":"","title":"Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care","status":"COMPLETED","sponsor":"Daniel Benjamin","startDate":"2011-11","conditions":"Adenovirus, Anesthesia, Anxiety","enrollment":3520},{"nctId":"NCT04149964","phase":"PHASE4","title":"Postoperative Pain Control in Septum and Sinus Surgery","status":"COMPLETED","sponsor":"Corewell Health East","startDate":"2019-11-27","conditions":"Post-operative Pain, Sinus Surgery","enrollment":65},{"nctId":"NCT02989597","phase":"PHASE4","title":"Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients","status":"TERMINATED","sponsor":"Montefiore Medical Center","startDate":"2017-07-29","conditions":"Pain, Postoperative","enrollment":10},{"nctId":"NCT03751423","phase":"PHASE3","title":"Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion","status":"SUSPENDED","sponsor":"Dr. Marie Eve Sophie Bussiere-Cote","startDate":"2019-06-10","conditions":"Abortion in First Trimester","enrollment":123},{"nctId":"NCT04696445","phase":"","title":"Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2020-10-01","conditions":"Opioid Use, Side Effect of Drug, Postoperative Pain","enrollment":34},{"nctId":"NCT03770806","phase":"NA","title":"Factors Affecting the Speed of Recovery After ACL Reconstruction","status":"COMPLETED","sponsor":"University of Washington","startDate":"2017-03-24","conditions":"Anterior Cruciate Ligament Injury, ACL Injury, ACL - 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Used for Moderate to severe acute pain, Moderate to severe chronic pain, Dyspnea relief in palliative care.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}